Dendronized Anionic Gold Nanoparticles: Synthesis, Characterization and Antiviral Activity
Authors
Peña González, Cornelia Emeritina; García Broncado, Pilar; Ottaviani, M. Francesca; Cangiotti, Michela; Fattori, Alberto; [et al.]Identifiers
Permanent link (URI): http://hdl.handle.net/10017/34039DOI: 10.1002 /chem .201504262
ISSN: 0947-6539
Publisher
Wiley
Date
2016-02-01Affiliation
Universidad de Alcalá. Departamento de Biomedicina y Biotecnología; Universidad de Alcalá. Departamento de Química Orgánica y Química InorgánicaFunders
Ministerio de Economía y Empresa
Comunidad de Madrid
Universidad de Alcalá
Bibliographic citation
Chemistry - A European Journal, 2016, v. 22, n. 9, p. 2987-2999
Keywords
Gold nanoparticles
Sulfonate carbosilane dendrons
Antivirus agents
HIV
EPR
Project
info:eu-repo/grantAgreement/MINECO//CTQ2011-23245/ES/DISEÑO DE NANOSISTEMAS DENDRÍTICOS BIFUNCIONALES DE NATURALEZA CARBOSILANO PARA SU APLICACIÓN EN BIOMEDICINA
info:eu-repo/grantAgreement/MINECO//CTQ-2014-54004-P/ES/DISEÑO DE SISTEMAS DENDRÍTICOS AVANZADOS PARA SU USO EN BIOMEDICINA, OBTENIDOS A TRAVÉS DE PROCESOS DE DENDRONIZACIÓN
info:eu-repo/grantAgreement/CAM//S2011%2FBMD-2351/ES/Nanosistemas Dendríticos para Aplicaciones Biomédicas - Dendritic Nanosystems for Biomedical Aplications
info:eu-repo/grantAgreement/UE//PT13%2F0010%2F0028/UE/Plataforma de Biobancos
info:eu-repo/grantAgreement/UE//PI13%2F02016/UE/Desarrollo y mecanismo de acción de dendrimeros como microbicidas para frenar la infección por el VIH por transmisión sexual (vaginal y anal): Prueba de concepto
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/acceptedVersion
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
(c) Wiley, 2016
Access rights
info:eu-repo/semantics/openAccess
Abstract
Anionic carbosilane dendrons decorated with sulfonate functions and with a thiol moiety at the focal point have been used to synthesize water soluble gold nanoparticles (AuNPs) by direct reaction of dendrons, gold precursor and reducing agent in water and also by place-exchange reaction. These nanoparticles have been characterized by nuclear magnetic resonance (NMR), transmission electron microscopy (TEM), thermogravimetric analysis (TGA), X-ray photoelectron spectroscopy (XPS), UV, elemental analysis, and Z potential. Also, the interacting ability of the anionic sulfonate functions was investigated by electron paramagnetic resonance (EPR) using copper(II) as a probe. It was found that the different structures and conformations of the AuNPs modulate the availability of sulfonate and thiol groups to be complexed by copper(II). Toxicity assays of AuNPs showed that those produced by direct reaction were less toxic than those obtained by ligand exchange. Inhibition of HIV-1 infection was higher for dendronized AuNPs than for dendrons.
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