Carbosilane cationic dendrimers synthesized by thiol-ene chemistry and their use as antibacterial agents

Abstract

+ in dendrimer structure have been studied by molecular dynamics. The antibacterial properties of these families of dendrimers have been evaluated against Gram-positive (Staphylococcus aureus CECT 240) and Gram-negative (Escherichia coli CECT 515) bacterial strains, and the results obtained have been compared with those obtained for related cationic carbosilane dendrimers functionalized by hydrosilylation reactions. These data stand out the relevance of the sulfur atom versus the silicon atom close to the dendrimer surface and the outer charge versus the inner charge. Finally, the stability of the most active first generation dendrimers vs. pH and temperature has also been studied.