Antibacterial and antifungal properties of dendronized silver and gold nanoparticles with cationic carbosilane dendrons

Authors
Peña González, Cornelia EmeritinaUniversity of Alcalá Author; Pedziwiatr-Webicka, Elzbieta; Martín Pérez, TaniaUniversity of Alcalá Author; Szewczyk, Eligia Maria; Copa Patiño, José LuisUniversity of Alcalá Author; [et al.]
Identifiers
Permanent link (URI): http://hdl.handle.net/10017/33959
DOI: 10.1016/j.ijpharm.2017.05.067
ISSN: 0378-5173
Publisher
Elsevier
Date
2017-08-01
Embargo end date
2018-08-01
Affiliation
Universidad de Alcalá. Departamento de Biomedicina y Biotecnología; Universidad de Alcalá. Departamento de Química Orgánica y Química Inorgánica
Funders
Ministerio de Economía y Empresa
Bibliographic citation
International Journal of Pharmaceutics, 2017, v. 528, n. , p. 55-61
Keywords
Silver nanoparticles
Gold nanoparticles
Dendrimers and dendrons
Carbosilane
Antibacterial
Antifungal
Project
CTQ-2014-54004-P (Ministerio de Economía y Empresa)
Document type
info:eu-repo/semantics/preprint
Version
info:eu-repo/semantics/submittedVersion
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
(c) Elsevier, 2014
Access rights
info:eu-repo/semantics/openAccess
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Abstract
Water soluble silver nanoparticles (AgNPs) capped with cationic carbosilane dendrons have been synthesized by direct reaction in water of dendrons, silver precursor and a reducing agent. These nanoparticles have been characterized by nuclear magnetic resonance (NMR), transmission electron microscopy (TEM), dynamic light scattering (DLS), thermogravimetric analysis (TGA), ultraviolet spectroscopy (UV), elemental analysis, and zeta potential (ZP). The antibacterial and antifungal properties of the cationic dendrons and dendronized AgNPs and AuNPs with these dendrons have been evaluated against Gram-negative and Gram-positive bacterial -including resistant strains- and yeast strains, respectively. The results stand out for the activity of AgNPs covered with first generation dendron compared with this free dendron and corresponding dendronized AuNPs.
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