Show simple item record

dc.contributor.authorSánchez-Nieves Fernández, Javier 
dc.contributor.authorFransen, Peter
dc.contributor.authorPulido, Daniel
dc.contributor.authorLlorente Heras, Raquel 
dc.contributor.authorMuñoz Fernández, María Ángeles
dc.contributor.authorAlbericio, Fernando
dc.contributor.authorRoyo, Miriam
dc.contributor.authorGómez Ramírez, Rafael 
dc.contributor.authorMata de la Mata, Francisco Javier de la 
dc.date.accessioned2018-07-26T11:07:06Z
dc.date.available2018-07-26T11:07:06Z
dc.date.issued2014-01-31
dc.identifier.bibliographicCitationEuropean Journal of Medicinal Chemistry, 2014, v. 76 , p. 43-52en
dc.identifier.issn0223-5234
dc.identifier.urihttp://hdl.handle.net/10017/33945
dc.description.abstractHere we synthesized carbosilane, generation 1 to 3, and PEG-based dendrons functionalized at the periphery with NHBoc groups and at the focal point with azide and alkyne moieties, respectively. The coupling of these two types of dendrons via click chemistry led to the formation of new hybrid dendrimers with two distinct moieties, the hydrophobic carbosilane and the hydrophilic PEG-based dendron. The protected dendrimers were transformed into cationic ammonium dendrimers. These unique amphiphilic dendrimers were studied as vectors for gene therapy against HIV in peripheral blood mononuclear cells (PBMC) and their performance was compared with that of a PEG-free carbosilane dendrimer. The presence of the PEG moiety afforded lower toxicities and evidenced a weaker interaction between dendrimers and siRNA when compared to the homodendrimer analogous. Both features, lower toxicity and lower dendriplex strength, are key properties for use of these vectors as carriers of nucleic material.en
dc.description.sponsorshipComunidad de Madrides_ES
dc.description.sponsorshipMinisterio de Sanidad y Consumoes_ES
dc.description.sponsorshipMinisterio de Economía y Empresaes_ES
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherElsevieren
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)en
dc.rights(c) Elsevier, 2014en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectDendrimersen
dc.subjectClick chemistryen
dc.subjectCarbosilaneen
dc.subjectPEGen
dc.subjectGene therapyen
dc.subjectHIVen
dc.titleAmphiphilic Cationic Carbosilane-PEG Dendrimers: Synthesis and Applications in Gene Therapyen
dc.typeinfo:eu-repo/semantics/articleen
dc.subject.ecienciaQuímicaes-
dc.subject.ecienciaChemistryen
dc.contributor.affiliationUniversidad de Alcalá. Departamento de Química Orgánica y Química Inorgánicaes-ES
dc.date.updated2018-07-26T09:53:01Z
dc.type.versioninfo:eu-repo/semantics/acceptedVersionen
dc.identifier.doi10.1016/j.ejmech.2014.01.061
dc.relation.projectIDPI061479 (Ministerio de Sanidad y Consumo)
dc.relation.projectIDRD06-0006-0035 (red Iris)
dc.relation.projectID24632/07(FIPSE)
dc.relation.projectIDNAN2007-31198-E (MNT-ERA NET 2007)
dc.relation.projectIDS-SAL-0159-2006 (Comunidad de Madrid)
dc.relation.projectIDS2011/BMD-2351 (Comunidad de Madrid)
dc.relation.projectIDSAF2011-30508-C02-01 (Ministerio de Economía y Empresa)
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen
dc.identifier.uxxiAR/0000021005
dc.identifier.publicationtitleEuropean Journal of Medicinal Chemistryen
dc.identifier.publicationvolume76
dc.identifier.publicationlastpage52
dc.identifier.publicationfirstpage43


Files in this item

Thumbnail

This item appears in the following Collection(s)

Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Este ítem está sujeto a una licencia Creative Commons.