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dc.contributor.authorRodríguez Berriguete, Gonzalo 
dc.contributor.authorOrtega Núñez, Miguel Ángel 
dc.contributor.authorTorrealba Abache, Norelia Rosa
dc.contributor.authorMartínez Onsurbe, María del Pilar 
dc.contributor.authorOlmedilla Arregui, Gabriel 
dc.contributor.authorPaniagua Gómez-Álvarez, Ricardo 
dc.contributor.authorGuil Cid, Manuel Esteban 
dc.contributor.authorFraile Laiz, Benito 
dc.contributor.authorRoyuela García, María del Mar 
dc.date.accessioned2018-03-13T15:17:29Z
dc.date.available2018-03-13T15:17:29Z
dc.date.issued2015
dc.identifier.bibliographicCitationBMC Cancer. 2015, v. 15, n. 809, p. 1-9en
dc.identifier.urihttp://hdl.handle.net/10017/32720
dc.description.abstractBackground: The expression status of apoptotic regulators, such as caspases and inhibitors of apoptosis proteins (IAPs), could reflect the aggressiveness of tumors and, therefore, could be useful as prognostic markers. We explored the associations between tumor expression of caspases and IAPs and clinicopathological features of prostate cancer – clinical and pathological T stage, Gleason score, preoperative serum PSA levels, perineural invasion, lymph node involvement, surgical margin status and overall survival – and evaluated its capability to predict biochemical progression after radical prostatectomy. Methods: Protein expression of caspases (procaspase-8, cleaved caspase-8, procaspase-3, cleaved caspase-3, caspase-7 and procaspase-9) and IAPs (cIAP1/2, cIAP2, NAIP, Survivin and XIAP) was analyzed by immunohistochemistry in radical prostatectomy samples from 84 prostate cancer patients. Spearman’s test, Kaplan-Meier curves, and univariate and multivariate Cox proportional hazard regression analysis were performed. Results: cIAP1/2, cIAP2, Survivin, procaspase-8, cleaved caspase-8, procaspase-3 and caspase-7 expression correlated with at least one clinicopathological feature of the disease. Patients negative for XIAP, procaspase-3 or cleaved caspase-3 had a significantly worse prognosis. Of note, XIAP, procaspase-3 and cleaved caspase-3 were predictors of biochemical progression independent of Gleason score and pathological T stage. Conclusions: Our results indicate that alterations in the expression of IAPs and caspases contribute to the malignant behavior of prostate tumors and suggest that tumor expression of XIAP, procaspase-3 and cleaved caspase-3 may help to identify prostate cancer patients at risk of progression.en
dc.description.sponsorshipInstituto de Salud Carlos IIIes_ES
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherBioMed Centralen
dc.rights© Rodríguez-Berriguete et al. Open access, 2015es_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacionalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectApoptosisen
dc.subjectCaspasesen
dc.subjectBiochemical progressionen
dc.subjectInhibitors of apoptosis proteinsen
dc.subjectProstate canceren
dc.titlePrognostic value of inhibitors of apoptosis proteins (IAPs) and caspases in prostate cancer: caspase-3 forms and XIAP predict biochemical progression after radical prostatectomyen
dc.typeinfo:eu-repo/semantics/articleen
dc.subject.ecienciaBiologíaes_ES
dc.subject.ecienciaBiologyen
dc.subject.ecienciaGenéticaes_ES
dc.subject.ecienciaGeneticsen
dc.subject.ecienciaCienciaes_ES
dc.subject.ecienciaScienceen
dc.contributor.affiliationUniversidad de Alcalá. Departamento de Biomedicina y Biotecnología. Unidad docente Biología Celular y Genéticaes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1186/s12885-015-1839-z
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dc.identifier.doi10.1186/s12885-015-1839-z
dc.relation.projectIDinfo:eu-repo/grantAgreement/ISCIII//PI13%2F1801/ESes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen
dc.identifier.publicationtitleBMC Canceren
dc.identifier.publicationvolume15
dc.identifier.publicationlastpage9
dc.identifier.publicationissue809
dc.identifier.pmid26507126
dc.subject.meshAgeden
dc.subject.meshBiomarkers, Tumoren
dc.subject.meshCaspase 3en
dc.subject.meshCohort Studiesen
dc.subject.meshDisease Progressionen
dc.subject.meshFollow-Up Studiesen
dc.subject.meshHumansen
dc.subject.meshInhibitor of Apoptosis Proteinsen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshPredictive Value of Testsen
dc.subject.meshPrognosisen
dc.subject.meshProstatectomyen
dc.subject.meshProstatic Neoplasmsen
dc.subject.meshX-Linked Inhibitor of Apoptosis Proteinen
dc.identifier.essn1471-2407


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© Rodríguez-Berriguete et al. Open access, 2015
Este ítem está sujeto a una licencia Creative Commons.