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Short synthesis and anti-rhinoviral activity of imidazo[1,2-a]pyridines: the effect of acyl groups at 3-position

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Authors
Hamdouchi, Chafiq; Ezquerra, Jesús; Vega Ramiro, Juan AntonioUniversity of Alcalá Author; Vaquero López, Juan J.; Álvarez-Builla Gómez, JulioUniversity of Alcalá Author; [et al.]
Identifiers
Permanent link (URI): http://hdl.handle.net/10017/3088
DOI: 10.1016/S0960-894X(99)00193-6
ISSN: 0960-894X
Publisher
Pergamon
Date
1999
Affiliation
Universidad de Alcalá. Departamento de Química Orgánica
Funders
This research was supported by a CDTI program (Plan concertado 96/0036) and the Spanish Farma III programme (Ministerio de Industria y Ministerio de Sanidad). We are also grateful to the Lilly Rhinovirus Action Group for their advice and interest in this work.
Bibliographic citation
Bioorganic & Medicinal Chemistry Letters, 1999, v. 9, n. 10, p. 1391-1394
Keywords
Enviroxime
Chemistry, Medicinal
Chemistry, Organic
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Publisher's version
http://dx.doi.org/10.1016/S0960-894X(99)00193-6
Rights
(c) Elsevier, 1999
Access rights
info:eu-repo/semantics/openAccess
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Abstract
Various 2-amino-3-acyl-6-[(E)-1-phenyl-2-N-methylcarbamoylvinyl]-imidazo[1,2-a]pyridines, structurally related to Enviroxime were prepared to determine the effect of acyl groups on the antirhinoviral activity. A short and efficient means for the construction of the imidazo nucleus as well as biological evaluation of the final compounds are disclosed.
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