Somatostatin content and binding in small intestinal mucosa from fed, fasted and refed rabbits

Authors
Roca, B.; Fernández-Valencia Rodríguez, RafaelUniversity of Alcalá Author; Rodríguez Sánchez, María Nelly; Arilla Ferreiro, EduardoUniversity of Alcalá Author
Identifiers
Permanent link (URI): http://hdl.handle.net/10017/3059
DOI: 10.1016/0024-3205(90)90439-X
ISSN: 0024-3205
Publisher
Pergamon
Date
1990
Affiliation
Universidad de Alcalá. Departamento de Bioquímica y Biología Molecular
Bibliographic citation
Life Sciences, 1990, v. 47, n. 22, p. 2041-2049
Keywords
Somatostatin
Intestinal mucosa
Rabbits
Project
PB87/0753 (Comisión Interministerial de Ciencia y Tecnología-CICYT)
88/0903 (Fondo de Investigaciones Sanitarias-FIS)
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Publisher's version
http://dx.doi.org/10.1016/0024-3205(90)90439-X
Rights
(c) Pergamon Press, 1990
Access rights
info:eu-repo/semantics/openAccess
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Abstract
The present study is an investigation of the effects of 12- to 96-hours' starvation and 96-hours' starvation plus 48-hours' refeeding on both somatostatin-like immunoreactivity (SLI) and cytosolic somatostatin binding sites in rabbit small intestinal mucosa. The SLI concentration increased after 24 h in duodenal and jejunal mucosa, but not in ileal mucosa, and reached its highest value after 96 h of fasting. The number of specific high and low-affinity somatostatin binding sites, but not their affinity, decreased with the duration of fasting in the same gut segments, refeeding of fasted animals resulted in a return to normal control values for small intestine mucosal SLI and somatostatin binding.
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