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Synthesis and cytotoxic activity of pyridazino[1 ',6 ': 1,2] pyrido[3,4-b]indol-5-inium derivatives as anti-cancer agents

dc.contributor.authorFontana, Alberto
dc.contributor.authorBenito Molinero, Enrique Javier 
dc.contributor.authorMartín Gutierrez, Justina
dc.contributor.authorSánchez, Nuria
dc.contributor.authorAlajarín Ferrández, Luis Ramón 
dc.contributor.authorVaquero López, Juan J.
dc.contributor.authorÁlvarez-Builla Gómez, Julio 
dc.contributor.authorLambel-Giraudet, Stéphanie
dc.contributor.authorLeonce, Stéphane
dc.contributor.authorPierré, Alain
dc.contributor.authorCaignard, Daniel
dc.date.accessioned2009-05-11T13:59:45Z
dc.date.available2009-05-11T13:59:45Z
dc.date.issued2002
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry Letters, 2002, v.12, n.18, p.2611-2614en
dc.identifier.issn0960-894X
dc.identifier.urihttp://hdl.handle.net/10017/2799
dc.description.abstractSeveral new pyridazino[1′,6′:1,2]pyrido[3,4-b]indol-5-inium derivatives were synthesised from β-carboline derivatives and their cytotoxic activity and effect on the cell cycle were evaluated against L1210 cancer cells.en
dc.description.sponsorshipComisión Interministerial de Ciencia y Tecnologíaes_ES
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherPergamonen
dc.rights© Elsevier, 2002en
dc.subjectFused benzimidazolium saltsen
dc.subjectDNA intercalating agentsen
dc.subjectSystemen
dc.subjectChemistry, Medicinalen
dc.subjectChemistry, Organicen
dc.titleSynthesis and cytotoxic activity of pyridazino[1 ',6 ': 1,2] pyrido[3,4-b]indol-5-inium derivatives as anti-cancer agentsen
dc.typeinfo:eu-repo/semantics/articleen
dc.subject.ecienciaCienciaes_ES
dc.subject.ecienciaQuímica orgánicaes_ES
dc.subject.ecienciaScienceen
dc.subject.ecienciaChemistry, organicen
dc.contributor.affiliationUniversidad de Alcalá. Departamento de Química Orgánica
dc.relation.publisherversionhttp://dx.doi.org/10.1016/S0960-894X(02)00472-9
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dc.identifier.doi10.1016/S0960-894X(02)00472-9
dc.relation.projectIDinfo:eu-repo/grantAgreement/CICYT//SAF98-0093/ES/Nuevos agentes citotoxicos basados en cationes de quinolicinio y aza-quinolicinio. Diseño, sintesis y caracterizacion de su interaccion con ADNes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen


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