Chemoselective addition of grignard reagents to alkoxycarbonylalkyl-N-imidazolium-N-methyl amides: synthesis of 4-oxo and homologous esters

Authors
Heras Muñoz, María Amor de lasUniversity of Alcalá Author; Vaquero López, Juan J.; García Navío, José LuisUniversity of Alcalá Author; Álvarez-Builla Gómez, JulioUniversity of Alcalá Author
Identifiers
Permanent link (URI): http://hdl.handle.net/10017/2707
DOI: 10.1016/S0040-4039(97)00159-7
ISSN: 0040-4039
Publisher
Pergamon
Date
1997
Affiliation
Universidad de Alcalá. Departamento de Química Orgánica
Funders
Ministerio de Educación y Ciencia
Bibliographic citation
Tetrahedron Letters, 1997, v.38, n.10, p.1817-1820
Keywords
Addition reaction
Grignard reagents role: RCT
Amides role
Chemoselective addn
Carboxylic acids role
Chemoselective
ADDN
Grignard
Imidazoliomethyl
Amide
Oxo
Ester
Project
QFN94-4619 (Comisió Interdepartamental de Recerça i Innovació Técnologica-CIRIT)
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Publisher's version
http://dx.doi.org/10.1016/S0040-4039(97)00159-7
Rights
© Elsevier, 1997
Access rights
info:eu-repo/semantics/openAccess
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Abstract
A method for the synthesis of 4-oxo and homologous esters is achieved by metalation of alkoxycarbonylalkyl-N-imidazolium-N-methyl amides with 1equiv of LDA followed by highly chemoselective addition of 1 equiv of a Grignard reagent.
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