dc.contributor.author | Castillo Romero, Rafael | |
dc.contributor.author | Reyes Prados, María José | |
dc.contributor.author | Izquierdo Ceinos, Ma Luisa | |
dc.contributor.author | Álvarez-Builla Gómez, Julio | |
dc.date.accessioned | 2009-04-29T14:10:11Z | |
dc.date.available | 2009-04-29T14:10:11Z | |
dc.date.issued | 2008 | |
dc.identifier.bibliographicCitation | Tetrahedron, 2008, v. 64, n. 7, p. 1351-1370 | en |
dc.identifier.issn | 0040-4020 | |
dc.identifier.uri | http://hdl.handle.net/10017/2690 | |
dc.description.abstract | An extensive study of Suzuki–Miyaura cross-coupling processes on N-pyridinium bromoazinyl aminides has been performed. Mono- and disubstitution on 5- and 3,5-bromo derivatives produced the corresponding aryl derivatives. In the disubstituted compounds regioselective substitution at the 3-position occurred, vicinal to the aminide nitrogen, and this was more evident in pyrazine derivatives. The commonly used strategy involving N-alkylation and reduction of the N–N bond gave rise to a series of 2-alkylamino-3,5-disubstituted-pyrazines. | en |
dc.description.sponsorship | The authors wish to thank the Comisión Interministerial de Ciencia y Tecnología (CICYT-BQU2001-1508 and CTQ2005-08902) and the Universidad de Alcalá (UAH GC2005/006) for financial support and the Ministerio de Educación y Ciencia (MEC) for two studentships (M.J.R. and R.C.). We also thank Professor Mijail Galajov for his assistance in the NMR study. | en |
dc.description.sponsorship | Comisión Interministerial de Ciencia y Tecnología | es_ES |
dc.description.sponsorship | Universidad de Alcalá | es_ES |
dc.description.sponsorship | Ministerio de Educación y Ciencia | es_ES |
dc.format.mimetype | application/pdf | en |
dc.language.iso | eng | en |
dc.publisher | Elsevier | en |
dc.rights | (c) Elsevier, 2008 | en |
dc.subject | Cross-coupling reactions | en |
dc.subject | Rapid analog syntheses | en |
dc.subject | Heteroaromatic-compounds | en |
dc.subject | Radical cyclization | en |
dc.subject | Derivatives | en |
dc.subject | Miyaura | en |
dc.subject | Aminides | en |
dc.subject | N-(2'-azinyl)aminides | en |
dc.subject | N-2'-pyridylaminide | en |
dc.subject | Heteroarylaminides | en |
dc.subject | Chemistry, Organic | en |
dc.title | Suzuki reaction on pyridinium N-haloheteroarylaminides: regioselective synthesis of 3,5-disubstituted 2-aminopyrazines | en |
dc.type | info:eu-repo/semantics/article | en |
dc.subject.eciencia | Bioquímica | es_ES |
dc.subject.eciencia | Biochemistry | en |
dc.subject.eciencia | Science | en |
dc.subject.eciencia | Ciencia | es_ES |
dc.contributor.affiliation | Universidad de Alcalá. Departamento de Química Orgánica | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1016/j.tet.2007.11.057 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | en |
dc.identifier.doi | 10.1016/j.tet.2007.11.057 | |
dc.relation.projectID | info:eu-repo/grantAgreement/CICYT//BQU2001-1508/ESQUIMIODIVERSIDAD: NUEVOS MÉTODOS DE SÍNTESIS EN PARALELO PARA LA OBTENCIÓN DE MUESTROTECAS PRODUCTOS DE INTERÉS BIOLÓGICO | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/CICYT//CTQ2005-08902/ES/N-AMIDAS DE AZINIO ESTABILIZADAS POR HETEROARILO: REACCIONES A TRAVÉS DE ORGANOPALADIOS, SÍNTESIS DE POLIAMINAS DENDRÍMERAS Y REACCIONES RADICALARIAS | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MEC//UAH GC2005%2F006/ES/N-AMINIDAS DE AZINIO ESTABILIZADAS POR HETEROARILO: REACCIONES A TRAVES DE ORGANOPALADIOS, SINTESIS DE POLIAMINAS DENDRÍMERAS Y REACCIONES RADICALARIAS | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | en |