Partial enterectomy decreases somatostatin-binding sites in residual intestine of rabbits

Authors
Colás Escudero, María BegoñaUniversity of Alcalá Author; Bodega Magro, GuillermoUniversity of Alcalá Author; Sanz, Manuel; Prieto Villapún, Juan CarlosUniversity of Alcalá Author; Arilla Ferreiro, EduardoUniversity of Alcalá Author
Identifiers
Permanent link (URI): http://hdl.handle.net/10017/2474
DOI: 10.1042/cs0740499
ISSN: 0143-5221
Publisher
Biochemical Society
Date
1988
Affiliation
Universidad de Alcalá. Departamento de Bioquímica y Biología Molecular
Bibliographic citation
Clinical Science, 1988, v. 74, n. 5, p. 499-505
Keywords
Cytosol
Enterectomy
Somatostatin binding
Project
86/911 (Fondo de Investigaciones Sanitarias-FISl)
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Publisher's version
http://www.clinsci.org/cs/074/cs0740499.htm
Rights
© The Biochemical Society and the Medical Research Society, 1988
Access rights
info:eu-repo/semantics/openAccess
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Abstract
Three weeks after partial enterectomy in the rabbit there was an increased somatostatin concentration and a decreased number of somatostatin-binding sites (without changes in the corresponding affinity values) in the cytosol of the residual intestinal tissue, except in the terminal ileum and the colon. Five weeks after surgery both the somatostatin concentration and the number of somatostatin-binding sites returned towards control values. These results suggest that an increase in bowel somatostatin content could lead to down-regulation of somatostatin-binding sites in the intestinal mucosa.
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