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Effect of cysteamine on cytosolic somatostatin binding-sites in rabbit duodenal mucosa

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Authors
González Guijarro, Luis A.; López Ruiz, María del PilarUniversity of Alcalá Author; Bodega Magro, GuillermoUniversity of Alcalá Author; Prieto Villapún, Juan CarlosUniversity of Alcalá Author; Arilla Ferreiro, EduardoUniversity of Alcalá Author
Identifiers
Permanent link (URI): http://hdl.handle.net/10017/2472
DOI: 10.1016/0014-4800(87)90061-X
ISSN: 0014-4800
Publisher
Academic Press
Date
1987
Affiliation
Universidad de Alcalá. Departamento de Bioquímica y Biología Molecular
Bibliographic citation
Experimental and molecular pathology, 1987, v. 46, n. 2, p. 153-158
Keywords
Somatostatin
Rabbit
Mucosa
Project
85/1213 (Fondo de Investigaciones Sanitarias-FIS)
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Publisher's version
http://dx.doi.org/10.1016/0014-4800(87)90061-X
Rights
(c) Academic Press, 1987
Access rights
info:eu-repo/semantics/openAccess
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Abstract
Administration of cysteamine in rabbits elicited a rapid depletion of both duodenal mucosa and plasma somatostatin. A significant reduction was observed within 5 min, returning toward control values by 150 min. The depletion of somatostatin was associated with an increase in the binding capacity and a decrease in the affinity of both high- and low-affinity binding sites present in cytosol of duodenal mucosa. Incubation of cytosolic fraction from control rabbits with 1 mM cysteamine did not modify somatostatin binding. Furthermore, addition of cysteamine at the time of binding assay did not affect the integrity of 125I-Tyr11-somatostatin. It is concluded that in vivo administration of cysteamine to rabbits depletes both duodenal mucosa and plasma somatostatin and leads to up-regulation of duodenal somatostatin binding sites.
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