Effects of fasting and refeeding on somatostatin concentration and binding to cytosol from rabbit gastric mucosa

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Authors
Roca, B.; Fernández-Valencia Rodríguez, RafaelUniversity of Alcalá Author; Arilla Ferreiro, EduardoUniversity of Alcalá Author
Identifiers
Permanent link (URI): http://hdl.handle.net/10017/2363
DOI: 10.1136/gut.29.5.642
ISSN: 0017-5749
Publisher
Nature Publishing Group
Date
1988
Academic Departments
Universidad de Alcalá. Departamento de Bioquímica y Biología Molecular
Teaching unit
Unidad Docente Bioquímica y Biología Molecular
Funders
Instituto de Salud Carlos III
Keywords
Somatostatin
Rabbit
Stomach
Mucosa
Project
info:eu-repo/grantAgreement/ISCIII//86%2F911/ES//
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Publisher's version
http://dx.doi.org/10.1136/gut.29.5.642
Rights
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Access rights
info:eu-repo/semantics/openAccess
Abstract
Somatostatin like immunoreactivity and the density of somatostatin binding sites were measured in stomach (fundus and antrum) from either fed, 12 to 96 hours fasted, or 96 hours fasted plus 48 hours refed rabbits. The somatostatin concentration increased in fundic and antral mucosa after 24 h and reached its highest value after 96 h of fasting. The number of specific somatostatin binding sites with high and low affinity decreased with the duration of fasting. Refeeding of fasted animals resulted in a normalisation to control values of gastric mucosal somatostatin and somatostatin binding.

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