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dc.contributor.authorMuñoz Acedo, Gema
dc.contributor.authorIzquierdo Claros, Rosa María 
dc.contributor.authorPuebla Jiménez, Lilian 
dc.contributor.authorRodríguez Martín, Eulalia 
dc.contributor.authorArilla Ferreiro, Eduardo 
dc.date.accessioned2008-11-17T11:38:44Z
dc.date.available2008-11-17T11:38:44Z
dc.date.issued1997
dc.identifier.bibliographicCitationMolecular Brain Research, 1997, v. 47, p. 117–124en
dc.identifier.issn0169-328X
dc.identifier.urihttp://hdl.handle.net/10017/2260
dc.description.abstractThere is evidence that suggests a reciprocal functional link between the serotonergic and the somatostatinergic system in the rat frontoparietal cortex. However, to date, the role of endogenous 5-hydroxytryptamine (serotonin) on the regulation of the somatostatin (SS) receptor-adenylyl cyclase (AC) system remains unclear. In the present study, the administration of fluoxetine (10 mg/kg i.p.), a 5-hydroxytryptamine uptake inhibitor in a single dose or administered daily for 14 days increased the number of specific [125I]Tyr11-SS receptors, with no change in the receptor affinity, in rat frontoparietal cortical membranes. However, the capacity of SS to inhibit forskolin (FK)-stimulated AC activity in these membranes was lower than in the control groups. The ability of the stable GTP analogue 5'-guanylylimidodiphosphate (Gpp(NH)p) to inhibit FK-stimulated AC activity in frontoparietal cortical membranes was also decreased in rats acutely and chronically treated with fluoxetine. p-Chloroamphetamine (5 mg/kg i.p.), which leads to a lasting reduction of 5-hydroxytryptamine innervation, administered,on days 1, 3 and 5 and the rats sacrificed 1 or 3 weeks after the first injection, decreased the number of SS receptors without changing the receptor affinity. In this experimental group, SS also caused a significantly lower inhibition of FK-stimulated AC activity. p-Chloroamphetamine had no effect on the ability of Gpp(NH)p to inhibit FK-stimulated AC activity in frontoparietal cortical membranes at all the time periods studied. The present results suggest that under normal circumstances some SS receptors are under a tonic stimulatory control through the serotonergic system.en
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherElsevieren
dc.rights(c) Elsevier Science, 1997en
dc.subjectFluoxetineen
dc.subjectp-Chloroamphetamineen
dc.subjectSomatostatin receptoren
dc.subjectAdenylyl cyclaseen
dc.subjectRaten
dc.subjectFrontoparietal cortexen
dc.titleInfluence of fluoxetine and p-chloroamphetamine on the somatostatin receptor-adenylyl cyclase system in the rat frontoparietal cortexen
dc.typeinfo:eu-repo/semantics/articleen
dc.subject.ecienciaBioquímicaes_ES
dc.subject.ecienciaBiochemistryen
dc.subject.ecienciaSCIENCEen
dc.subject.ecienciaCIENCIAes_ES
dc.contributor.affiliationUniversidad de Alcalá. Departamento de Bioquímica y Biología Molecular
dc.relation.publisherversionhttp://dx.doi.org/10.1016/S0169-328X(97)00038-7
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dc.identifier.doi10.1016/S0169-328X(97)00038-7
dc.relation.projectIDPM95-0041 (Ministerio de Educación y Cultura)
dc.relation.projectID001/96 (Universidad de Alcalá)
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen


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