dc.contributor.author | Muñoz Acedo, Gema | |
dc.contributor.author | Izquierdo Claros, Rosa María | |
dc.contributor.author | Puebla Jiménez, Lilian | |
dc.contributor.author | Rodríguez Martín, Eulalia | |
dc.contributor.author | Arilla Ferreiro, Eduardo | |
dc.date.accessioned | 2008-11-17T11:38:44Z | |
dc.date.available | 2008-11-17T11:38:44Z | |
dc.date.issued | 1997 | |
dc.identifier.bibliographicCitation | Molecular Brain Research, 1997, v. 47, p. 117–124 | en |
dc.identifier.issn | 0169-328X | |
dc.identifier.uri | http://hdl.handle.net/10017/2260 | |
dc.description.abstract | There is evidence that suggests a reciprocal functional link between the serotonergic and the somatostatinergic system in the rat frontoparietal cortex. However, to date, the role of endogenous 5-hydroxytryptamine (serotonin) on the regulation of the somatostatin (SS) receptor-adenylyl cyclase (AC) system remains unclear. In the present study, the administration of fluoxetine (10 mg/kg i.p.), a 5-hydroxytryptamine uptake inhibitor in a single dose or administered daily for 14 days increased the number of specific [125I]Tyr11-SS receptors, with no change in the receptor affinity, in rat frontoparietal cortical membranes. However, the capacity of SS to inhibit forskolin (FK)-stimulated AC activity in these membranes was lower than in the control groups. The ability of the stable GTP analogue 5'-guanylylimidodiphosphate (Gpp(NH)p) to inhibit FK-stimulated AC activity in frontoparietal cortical membranes was also decreased in rats acutely and chronically treated with fluoxetine. p-Chloroamphetamine (5 mg/kg i.p.), which leads to a lasting reduction of 5-hydroxytryptamine innervation, administered,on days 1, 3 and 5 and the rats sacrificed 1 or 3 weeks after the first injection, decreased the number of SS receptors without changing the receptor affinity. In this experimental group, SS also caused a significantly lower inhibition of FK-stimulated AC activity. p-Chloroamphetamine had no effect on the ability of Gpp(NH)p to inhibit FK-stimulated AC activity in frontoparietal cortical membranes at all the time periods studied. The present results suggest that under normal circumstances some SS receptors are under a tonic stimulatory control through the serotonergic system. | en |
dc.description.sponsorship | Ministerio de Educación y Cultura | es_ES |
dc.description.sponsorship | Universidad de Alcalá | es_ES |
dc.format.mimetype | application/pdf | en |
dc.language.iso | eng | en |
dc.publisher | Elsevier | en |
dc.rights | (c) Elsevier Science, 1997 | en |
dc.subject | Fluoxetine | en |
dc.subject | p-Chloroamphetamine | en |
dc.subject | Somatostatin receptor | en |
dc.subject | Adenylyl cyclase | en |
dc.subject | Rat | en |
dc.subject | Frontoparietal cortex | en |
dc.title | Influence of fluoxetine and p-chloroamphetamine on the somatostatin receptor-adenylyl cyclase system in the rat frontoparietal cortex | en |
dc.type | info:eu-repo/semantics/article | en |
dc.subject.eciencia | Bioquímica | es_ES |
dc.subject.eciencia | Biochemistry | en |
dc.subject.eciencia | Science | en |
dc.subject.eciencia | Ciencia | es_ES |
dc.contributor.affiliation | Universidad de Alcalá. Departamento de Bioquímica y Biología Molecular | |
dc.relation.publisherversion | http://dx.doi.org/10.1016/S0169-328X(97)00038-7 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | en |
dc.identifier.doi | 10.1016/S0169-328X(97)00038-7 | |
dc.relation.projectID | info:eu-repo/grantAgreement/MEC//PM95-0041/ES/EFECTO DEL OXIDO NITRICO SOBRE EL SISTEMA RECEPTOR-EFECTOR DE LA SOMATOSTATINA EN EL CEREBRO HUMANO Y DE RATA | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/UAH//001%2F96/ES/REGULACION DEL SISTEMA RECEPTOR-EFECTOR DE LA SOMATOSTATINA POR EL NEUROPEPTIDO Y (NPY) EN EL CEREBRO DE LA RATA | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | en |