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dc.contributor.authorBarrios Sabador, Vicente
dc.contributor.authorPuebla Jiménez, Lilian 
dc.contributor.authorBoyano Adánez, María del Carmen 
dc.contributor.authorSanz, Manuel
dc.contributor.authorSoriano Guillén, Leandro
dc.contributor.authorArilla Ferreiro, Eduardo 
dc.date.accessioned2008-11-14T11:17:39Z
dc.date.available2008-11-14T11:17:39Z
dc.date.issued2005
dc.identifier.bibliographicCitationLife Sciences, 2005, v. 77, n. 10, p. 1094 – 1105en
dc.identifier.issn0024-3205
dc.identifier.urihttp://hdl.handle.net/10017/2247
dc.description.abstractChronic ethanol ingestion decreases the number of somatostatin (SRIF) receptors in the rat frontoparietal cortex and female sex hormones modulate the effects of ethanol in the brain. Therefore, we investigated the differential effects of ethanol consumption on the SRIFergic system in the frontoparietal cortex of virgin and parturient rats given ethanol in their drinking water before and during gestation. In parturient rats, ethanol consumption decreased the density of SRIF receptors (25%, p < 0.01 vs control parturient group) whereas the SRIF-like immunoreactivity (SRIF-LI) content was increased (140%, p < 0.01). In virgin rats, ethanol ingestion decreased the density of SRIF receptors (42%, p < 0.01) more than in alcoholic parturient rats. SRIF-LI levels were unaffected. The inhibitory effect of SRIF on basal and forskolin-stimulated adenylyl cyclase was significantly lower in alcoholic virgin rats as compared to alcoholic parturient rats. No differences in the levels of the G inhibitory (Gi) ¿1 and Gi¿2 proteins were observed among the experimental groups. These results suggest that gestation may confer partial resistance to the ethanol-induced effect on the SRIFergic system.en
dc.description.sponsorshipMinisterio de Ciencia y Tecnologíaes_ES
dc.description.sponsorshipInstituto de Salud Carlos IIIes_ES
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherElsevieren
dc.rights(c) Elsevier, 2005en
dc.subjectEthanolen
dc.subjectSomatostatinen
dc.subjectGestationen
dc.subjectFrontoparietal cortexen
dc.subjectAdenylyl cyclaseen
dc.subjectVirgin ratsen
dc.titleDifferential effects of ethanol ingestion on somatostatin content,somatostatin receptors and adenylyl cyclase activity in thefrontoparietal cortex of virgin and parturient ratsen
dc.typeinfo:eu-repo/semantics/articleen
dc.subject.ecienciaBioquímicaes_ES
dc.subject.ecienciaBiochemistryen
dc.subject.ecienciaScienceen
dc.subject.ecienciaCienciaes_ES
dc.contributor.affiliationUniversidad de Alcalá. Departamento de Bioquímica y Biología Molecular
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.lfs.2005.01.019
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dc.identifier.doi10.1016/j.lfs.2005.01.019
dc.relation.projectIDinfo:eu-repo/grantAgreement/MICYT//SAF2003-08052/ES/ESTUDIO DEL SISTEMA SOMATOSTATINÉRGICO DEL SISTEMA NERVIOSO CENTRAL DE LA RATA LEWIS CON ENCEFALOMIELITIS ALÉRGICA EXPERIMENTALes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ISCIII//PI02%2F1241/ES//es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen


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