Differential effects of ethanol ingestion on somatostatin content,somatostatin receptors and adenylyl cyclase activity in thefrontoparietal cortex of virgin and parturient rats

Authors
Barrios Sabador, Vicente; Puebla Jiménez, LilianUniversity of Alcalá Author; Boyano Adánez, María del CarmenUniversity of Alcalá Author; Sanz, Manuel; Soriano Guillén, Leandro; [et al.]
Identifiers
Permanent link (URI): http://hdl.handle.net/10017/2247
DOI: 10.1016/j.lfs.2005.01.019
ISSN: 0024-3205
Publisher
Elsevier
Date
2005
Affiliation
Universidad de Alcalá. Departamento de Bioquímica y Biología Molecular
Bibliographic citation
Life Sciences, 2005, v. 77, n. 10, p. 1094 – 1105
Keywords
Ethanol
Somatostatin
Gestation
Frontoparietal cortex
Adenylyl cyclase
Virgin rats
Project
SAF2003-08052 (Ministerio de Ciencia y Tecnología)
PI02/1241 (Fondo de Investigaciones Sanitarias-FIS)
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Publisher's version
http://dx.doi.org/10.1016/j.lfs.2005.01.019
Rights
(c) Elsevier, 2005
Access rights
info:eu-repo/semantics/openAccess
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Abstract
Chronic ethanol ingestion decreases the number of somatostatin (SRIF) receptors in the rat frontoparietal cortex and female sex hormones modulate the effects of ethanol in the brain. Therefore, we investigated the differential effects of ethanol consumption on the SRIFergic system in the frontoparietal cortex of virgin and parturient rats given ethanol in their drinking water before and during gestation. In parturient rats, ethanol consumption decreased the density of SRIF receptors (25%, p < 0.01 vs control parturient group) whereas the SRIF-like immunoreactivity (SRIF-LI) content was increased (140%, p < 0.01). In virgin rats, ethanol ingestion decreased the density of SRIF receptors (42%, p < 0.01) more than in alcoholic parturient rats. SRIF-LI levels were unaffected. The inhibitory effect of SRIF on basal and forskolin-stimulated adenylyl cyclase was significantly lower in alcoholic virgin rats as compared to alcoholic parturient rats. No differences in the levels of the G inhibitory (Gi) ¿1 and Gi¿2 proteins were observed among the experimental groups. These results suggest that gestation may confer partial resistance to the ethanol-induced effect on the SRIFergic system.
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