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dc.contributor.authorRodríguez Martín, Eulalia 
dc.contributor.authorMuñoz Acedo, Gema
dc.contributor.authorPuebla Jiménez, Lilian 
dc.contributor.authorArilla Ferreiro, Eduardo 
dc.date.accessioned2008-11-10T09:21:12Z
dc.date.available2008-11-10T09:21:12Z
dc.date.issued1999
dc.identifier.bibliographicCitationBiochimica et Biophysica Acta, 1999, v. 1450, n. 1, p. 61-67en
dc.identifier.issn0006-3002
dc.identifier.urihttp://hdl.handle.net/10017/2175
dc.description.abstractNitric oxide (NO) and somatostatin (SS) are two important mediators of the exocrine and endocrine pancreas, exerting opposite effects on this organ. There is strong evidence suggesting an interaction between pancreatic NO and SS. The aim of this study was to determine whether L-arginine (L-Arg), the substrate for NO synthase (NOS), and Nω-nitro-L-arginine methyl ester (L-NAME), a NOS inhibitor, regulate pancreatic somatostatin-like immunoreactivity (SSLI) content and the SS mechanism of action in pancreatic acinar cell membranes. L-Arg (150 mg/kg, intraperitoneally (i.p.)), L-NAME (50 mg/kg, i.p.) or L-NAME plus L-Arg were injected twice daily at 8 h intervals for 8 days. L-Arg decreased pancreatic SSLI content as well as the number of SS receptors in pancreatic acinar cell membranes whereas L-NAME increased both parameters. The stable SS analogue SMS 201-995 induced a significantly lower inhibition of forskolin-stimulated adenylyl cyclase activity in pancreatic acinar cell membranes from L-Arg-treated rats whereas an increased inhibition was observed in pancreatic acinar membranes from L-NAME-treated rats. These results indicate that the NO system may contribute to the regulation of the pancreatic somatostatinergic system.en
dc.description.sponsorshipMinisterio de Educación y Culturaes_ES
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherElsevieren
dc.rights(c) Elsevier, 1999en
dc.subjectNitric oxideen
dc.subjectSomatostatin receptoren
dc.subjectAdenylyl cyclaseen
dc.subjectSomatostatin-like immunoreactivityen
dc.subjectPancreatic acinar membraneen
dc.subjectRaten
dc.titleEffect of nitric oxide on the somatostatinergic system in the rat exocrine pancreasen
dc.typeinfo:eu-repo/semantics/articleen
dc.subject.ecienciaBioquímicaes_ES
dc.subject.ecienciaBiochemistryen
dc.subject.ecienciaScienceen
dc.subject.ecienciaCienciaes_ES
dc.contributor.affiliationUniversidad de Alcalá. Departamento de Bioquímica y Biología Moleculares_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1016/S0167-4889(99)00032-4
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dc.identifier.doi10.1016/S0167-4889(99)00032-4
dc.relation.projectIDinfo:eu-repo/grantAgreement/MEC//PM95-0041/ES/EFECTO DEL OXIDO NITRICO SOBRE EL SISTEMA RECEPTOR-EFECTOR DE LA SOMATOSTATINA EN EL CEREBRO HUMANO Y DE RATAes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen


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