%0 Journal Article 
%A Alique Aguilar, Matilde
%A Sánchez-López E, Elsa
%A Bodega Magro, Guillermo
%A Giannarelli, Chiara
%A Carracedo Añón, Julia María
%A Ramírez Chamond, Manuel Rafael
%T Hypoxia-Inducible Factor-1alfa: The Master Regulator of Endothelial Cell Senescence in Vascular Aging
%D 2020
%@ 2073-4409
%U http://hdl.handle.net/10017/51267
%X Aging is one of the hottest topics in biomedical research. Advances in research and
medicine have helped to preserve human health, leading to an extension of life expectancy. However,
the extension of life is an irreversible process that is accompanied by the development of aging-related
conditions such as weakness, slower metabolism, and sti ness of vessels. It also debated that
aging can be considered an actual disease with aging-derived comorbidities, including cancer or
cardiovascular disease. Currently, cardiovascular disorders, including atherosclerosis, are considered
as premature aging and represent the first causes of death in developed countries, accounting for 31%
of annual deaths globally. Emerging evidence has identified hypoxia-inducible factor-1  as a critical
transcription factor with an essential role in aging-related pathology, in particular, regulating cellular
senescence associated with cardiovascular aging. In this review, we will focus on the regulation
of senescence mediated by hypoxia-inducible factor-1  in age-related pathologies, with particular
emphasis on the crosstalk between endothelial and vascular cells in age-associated atherosclerotic
lesions. More specifically, we will focus on the characteristics and mechanisms by which cells within
the vascular wall, including endothelial and vascular cells, achieve a senescent phenotype.
%K Hypoxia-inducible factor-1alfa (HIF1alfa)
%K Vascular aging
%K Senescent cells
%K Endothelial cells
%K Vascular smooth muscle cells
%K Atherosclerosis
%K Extracellular vesicles
%K Medicina
%K Medicine
%~ Biblioteca Universidad de Alcala