%0 Journal Article 
%A Marina Alegre, María Luisa
%A Plaza del Moral, Merichel
%A Domínguez Rodríguez, Gloria
%A Sahelices Garrido-Lestache, Cristina
%T A Sustainable Approach for Extracting Non-Extractable Phenolic Compounds from Mangosteen Peel Using Ultrasound-Assisted Extraction and Natural Deep Eutectic
Solvents
%D 2021
%@ 2076-3417
%U http://hdl.handle.net/10017/48667
%X Mangosteen (Garcinia mangostana L.) peel is a potential source of phenolic compounds with beneficial properties. Natural deep eutectic solvents (NaDES) have been
considered an environmentally friendly and cheap alternative to conventional
organic solvents. In this work, a green extraction methodology was developed
using ultrasound-assisted extraction (UAE) and NaDES for the extraction of
antioxidant non-extractable polyphenols (NEPs) from mangosteen peel. To select
the best NaDES to extract NEPs from mangosteen peel, seven NaDES were studied.
Antioxidant capacity and total phenolic and proanthocyanidin contents were
determined for the extracts. The molecular weights for the NEPs present in
those extracts were evaluated by size exclusion chromatography. Experimental
results showed that choline chloride&-lactic acid (1:2) was the NaDES allowing
the highest antioxidant proanthocyanidin content in the extracts. A Box&-Behnken
experimental design was employed to optimize the main parameters in UAE with
NaDES: water percentage, ultrasound amplitude, and extraction time. The optimal
extraction conditions were 18.8% (v/v) water, 60% ultrasound amplitude, and 15
min as the extraction time. In addition, the cytotoxicity of the NEP extracts
obtained under optimal extraction conditions was evaluated. Results indicated
for the first time that the use of NaDES in combination with UAE could be a
sustainable alternative for the extraction of antioxidant NEPs from mangosteen
peel for important applications in the food, pharmaceutical, agrochemical, and
cosmetic fields, as the extracts presented low cytotoxicity.
%K natural deep eutectic solvent
%K sustainable extraction
%K non-extractable polyphenols
%K mangosteen peel
%K ultrasound-assisted extraction
%K response surface methodology
%K Química
%K Chemistry
%~ Biblioteca Universidad de Alcala