%0 Journal Article %A Siro Herrero, Jorge G. %A Ramos González, Andrés %A Vaquero López, Juan J. %A Álvarez-Builla Gómez, Julio %A García Navío, José Luis %T Optimized synthesis of di, tri and tetrafused pyridazinium cations %D 2000 %@ 0040-4020 %U http://hdl.handle.net/10017/4192 %X By combining two complementary statistical techniques (fractional factorial experimental design and simplex operation) the synthesis of the parent pyrido[1,2-b]-pyridazinium cation has been successfully carried out (the yield was improved from less than 10 to 65%) by basic condensation of 2-methyl-1-aminopyridinium mesitylenesulfonate and [1,4]dioxane-2,3-diol. Using the optimized reaction conditions, other related heterocyclic cations could be prepared, and two interesting examples are now reported. %K Westphal %K Condensations %K Polycyclic heterocyclic ions %K Computer-assisted methods %K Ciencia %K Química orgánica %K Science %K Chemistry, organic %~ Biblioteca Universidad de Alcala