%0 Journal Article 
%A Díaz Martínez, Adolfo
%A Siro Herrero, Jorge G.
%A García Navío, José Luis
%A Vaquero López, Juan J.
%A Álvarez-Builla Gómez, Julio
%T A stereoselective synthesis of (R)-(-)-rolipram from L-glutamic acid
%D 1997
%@ 0039-7881
%U http://hdl.handle.net/10017/3591
%X A stereoselective synthesis of (R)-(-)-rolipram from L-glutamic acid is described. The key step is a stereoselective Michael addition of an arylcuprate to a modified pyroglutamic derivative which acts as the template to induce the stereoselectivity. Facile manipulation of the enantiomerically pure Michael product afforded the expected therapeutic agent.
%K Glutamic acid
%K Rolipram
%K Article
%K Central nervous system disease
%K Chemical modification
%K Chirality
%K Drug synthesis
%K Enantiomer
%K Reaction analysis
%K Stereochemistry
%K Ciencia
%K Química orgánica
%K Science
%K Chemistry, organic
%~ Biblioteca Universidad de Alcala