%0 Journal Article %A Villarroya, Mercedes %A Gandía, Luis %A López, Manuela G. %A García, Antonio G. %A Cueto, Sénida %A García Navío, José Luis %A Álvarez-Builla Gómez, Julio %T Synthesis and pharmacology of alkanediguanidinium compounds that block the neuronal nicotinic acetylcholine receptor %D 1996 %@ 0968-0896 %U http://hdl.handle.net/10017/3513 %X Taking as models the polyamine toxin fraction FTX from the funnel-web spider venom, and the guanidinium moiety of guanethidine, a series of azaalkane-1,omega-diguanidinium salts were obtained. Some of them blocked ion fluxes through the neuronal nicotinic receptors for acetylcholine (nAChR). The blockade was exerted at submicromolar concentrations, suggesting a highly selective interaction with the nAChR. In fact, the active compounds on the nAChR ion channel did not recognize the voltage-dependent Na+ or Ca2+ channels of bovine adrenal chromaffin cells. Therefore, these compounds may be useful tools to clarify the functions of nAChR receptors in the central and peripheral nervous systems. %K Bovine chromaffin cells %K Calcium channels %K FTX %K Separation %K Toxin %K Biochemistry & Molecular Biology %K Ciencia %K Química orgánica %K Science %K Chemistry, organic %~ Biblioteca Universidad de Alcala