%0 Journal Article 
%A Rodríguez Berriguete, Gonzalo
%A Ortega Núñez, Miguel Ángel
%A Torrealba Abache, Norelia Rosa
%A Martínez Onsurbe, María del Pilar
%A Olmedilla Arregui, Gabriel
%A Paniagua Gómez-Álvarez, Ricardo
%A Guil Cid, Manuel Esteban
%A Fraile Laiz, Benito
%A Royuela García, María del Mar
%T Prognostic value of inhibitors of apoptosis proteins (IAPs) and caspases in prostate cancer: caspase-3 forms and XIAP predict biochemical progression after radical prostatectomy
%D 2015
%U http://hdl.handle.net/10017/32720
%X Background: The expression status of apoptotic regulators, such as caspases and inhibitors of apoptosis proteins (IAPs), could reflect the aggressiveness of tumors and, therefore, could be useful as prognostic markers. We explored the associations between tumor expression of caspases and IAPs and clinicopathological features of prostate cancer – clinical and pathological T stage, Gleason score, preoperative serum PSA levels, perineural invasion, lymph node involvement, surgical margin status and overall survival – and evaluated its capability to predict biochemical
progression after radical prostatectomy.
Methods: Protein expression of caspases (procaspase-8, cleaved caspase-8, procaspase-3, cleaved caspase-3,
caspase-7 and procaspase-9) and IAPs (cIAP1/2, cIAP2, NAIP, Survivin and XIAP) was analyzed by immunohistochemistry
in radical prostatectomy samples from 84 prostate cancer patients. Spearman’s test, Kaplan-Meier curves, and univariate
and multivariate Cox proportional hazard regression analysis were performed.
Results: cIAP1/2, cIAP2, Survivin, procaspase-8, cleaved caspase-8, procaspase-3 and caspase-7 expression correlated
with at least one clinicopathological feature of the disease. Patients negative for XIAP, procaspase-3 or cleaved
caspase-3 had a significantly worse prognosis. Of note, XIAP, procaspase-3 and cleaved caspase-3 were predictors
of biochemical progression independent of Gleason score and pathological T stage.
Conclusions: Our results indicate that alterations in the expression of IAPs and caspases contribute to the
malignant behavior of prostate tumors and suggest that tumor expression of XIAP, procaspase-3 and cleaved
caspase-3 may help to identify prostate cancer patients at risk of progression.
%K Apoptosis
%K Caspases
%K Biochemical progression
%K Inhibitors of apoptosis proteins
%K Prostate cancer
%K Biología
%K Biology
%K Genética
%K Genetics
%K Ciencia
%K Science
%K Aged
%K Biomarkers, Tumor
%K Caspase 3
%K Cohort Studies
%K Disease Progression
%K Follow-Up Studies
%K Humans
%K Inhibitor of Apoptosis Proteins
%K Male
%K Middle Aged
%K Predictive Value of Tests
%K Prognosis
%K Prostatectomy
%K Prostatic Neoplasms
%K X-Linked Inhibitor of Apoptosis Protein
%~ Biblioteca Universidad de Alcala