%0 Journal Article %A Castillo Romero, Rafael %A Reyes Prados, María José %A Izquierdo Ceinos, Ma Luisa %A Álvarez-Builla Gómez, Julio %T Suzuki reaction on pyridinium N-haloheteroarylaminides: regioselective synthesis of 3,5-disubstituted 2-aminopyrazines %D 2008 %@ 0040-4020 %U http://hdl.handle.net/10017/2690 %X An extensive study of Suzuki–Miyaura cross-coupling processes on N-pyridinium bromoazinyl aminides has been performed. Mono- and disubstitution on 5- and 3,5-bromo derivatives produced the corresponding aryl derivatives. In the disubstituted compounds regioselective substitution at the 3-position occurred, vicinal to the aminide nitrogen, and this was more evident in pyrazine derivatives. The commonly used strategy involving N-alkylation and reduction of the N–N bond gave rise to a series of 2-alkylamino-3,5-disubstituted-pyrazines. %K Cross-coupling reactions %K Rapid analog syntheses %K Heteroaromatic-compounds %K Radical cyclization %K Derivatives %K Miyaura %K Aminides %K N-(2'-azinyl)aminides %K N-2'-pyridylaminide %K Heteroarylaminides %K Chemistry, Organic %K Bioquímica %K Biochemistry %K Science %K Ciencia %~ Biblioteca Universidad de Alcala