%0 Journal Article 
%A González Guijarro, Luis A.
%A López Ruiz, María del Pilar
%A Bodega Magro, Guillermo
%A Prieto Villapún, Juan Carlos
%A Arilla Ferreiro, Eduardo
%T Effect of cysteamine on cytosolic somatostatin binding-sites in rabbit duodenal mucosa
%D 1987
%@ 0014-4800
%U http://hdl.handle.net/10017/2472
%X Administration of cysteamine in rabbits elicited a rapid depletion of both duodenal mucosa and plasma somatostatin. A significant reduction was observed within 5 min, returning toward control values by 150 min. The depletion of somatostatin was associated with an increase in the binding capacity and a decrease in the affinity of both high- and low-affinity binding sites present in cytosol of duodenal mucosa. Incubation of cytosolic fraction from control rabbits with 1 mM cysteamine did not modify somatostatin binding. Furthermore, addition of cysteamine at the time of binding assay did not affect the integrity of 125I-Tyr11-somatostatin. It is concluded that in vivo administration of cysteamine to rabbits depletes both duodenal mucosa and plasma somatostatin and leads to up-regulation of duodenal somatostatin binding sites.
%K Somatostatin
%K Rabbit
%K Mucosa
%K Bioquímica
%K Biochemistry
%K Science
%K Ciencia
%~ Biblioteca Universidad de Alcala