%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Luis de Santiago, Eva Sánchez-Morla, Román Blanco, Juan Manuel Miguel, Carlos Amo, Miguel Ortiz del Castillo, Almudena López, Luciano Boquete
Empirical mode decomposition processing to improve multifocal-visual-evoked-potential signal analysis in multiple sclerosis
www.plosone.org
www.plosone.org
endstream
endobj
3 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 13 0 R/Contents 14 0 R/TrimBox[0 0 612 792]>>
endobj
13 0 obj
[15 0 R 16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R 34 0 R 35 0 R]
endobj
15 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194964.ref001)>>
endobj
16 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194964.ref002)>>
endobj
17 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194964.ref003)>>
endobj
18 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194964.ref004)>>
endobj
19 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194964.ref005)>>
endobj
20 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194964.ref007)>>
endobj
21 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194964.ref008)>>
endobj
22 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194964.ref009)>>
endobj
23 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194964.ref002)>>
endobj
24 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194964.ref010)>>
endobj
25 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194964.ref011)>>
endobj
26 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194964.ref012)>>
endobj
27 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194964.ref013)>>
endobj
28 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194964.ref014)>>
endobj
29 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194964.ref013)>>
endobj
30 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194964.ref015)>>
endobj
31 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194964.ref016)>>
endobj
32 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194964.ref015)>>
endobj
33 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194964.ref017)>>
endobj
34 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194964.ref018)>>
endobj
35 0 obj
<>/Border[0 0 0]/A 36 0 R>>
endobj
36 0 obj
<>
endobj
14 0 obj
[37 0 R 38 0 R 39 0 R 40 0 R 41 0 R 42 0 R 43 0 R 44 0 R 45 0 R 46 0 R 47 0 R 48 0 R 49 0 R 50 0 R 51 0 R 52 0 R 53 0 R 54 0 R 55 0 R 56 0 R 57 0 R]
endobj
37 0 obj
<>stream
q
0.45 0.36 0.35 0.01 k
0 w
575.9997 647.9101 m
199.9998 647.9101 l
199.9998 648.4102 l
575.9997 648.4102 l
f*
0.83 0.64 0.02 0 k
532.8567 511.8803 m
537.6189 511.8803 l
h
f*
547.2 498.8976 m
551.9622 498.8976 l
h
f*
548.3339 472.8756 m
553.0961 472.8756 l
h
f*
555.3071 472.8756 m
560.0693 472.8756 l
h
f*
263.7354 459.8929 m
268.4976 459.8929 l
h
f*
273.6567 459.8929 m
278.4189 459.8929 l
h
f*
550.4882 407.9055 m
555.2504 407.9055 l
h
f*
557.5181 407.9055 m
562.2803 407.9055 l
h
f*
394.5827 394.8661 m
399.2882 394.8661 l
h
f*
480.5858 329.8961 m
490.1102 329.8961 l
h
f*
506.6079 316.8567 m
516.0756 316.8567 l
h
f*
515.452 303.874 m
524.9764 303.874 l
h
f*
238.8472 290.8913 m
248.3717 290.8913 l
h
f*
420.3213 290.8913 m
429.8457 290.8913 l
h
f*
352.8567 198.9354 m
362.3811 198.9354 l
h
f*
364.5921 198.9354 m
374.1165 198.9354 l
h
f*
229.4362 185.8961 m
238.9606 185.8961 l
h
f*
475.9937 172.9134 m
485.5181 172.9134 l
h
f*
486.9354 120.926 m
496.4598 120.926 l
h
f*
392.5417 107.9433 m
402.0661 107.9433 l
h
f*
0 g
1 j
1 J
11.4998 0 0 11.4998 200.0125 706.3937 cm
BT
/F2 1 Tf
1 TL
-0.0035 Tc
0 0 Td
(Conclusions)Tj
ET
Q
q
1 j
1 J
0 w
9.5 0 0 9.5 200.0125 689.3858 cm
BT
/F0 1 Tf
1 TL
-0.0042 Tc
0 0 Td
(Filtering)Tj
3.7297 0 Td
(mfVEP)Tj
3.3181 0 Td
(signals)Tj
3.2881 0 Td
(using)Tj
2.5781 0 Td
(the)Tj
1.5933 0 Td
(EMD)Tj
2.4289 0 Td
(algorithm)Tj
4.2847 0 Td
(will)Tj
1.5815 0 Td
(result)Tj
2.6317 0 Td
(in)Tj
0.9847 0 Td
(better)Tj
2.751 0 Td
(identification)Tj
5.6992 0 Td
(of)Tj
1.0503 0 Td
(subjects)Tj
-35.9193 -1.474 Td
(at)Tj
1.0443 0 Td
(risk)Tj
1.7604 0 Td
(of)Tj
1.0444 0 Td
(developing)Tj
4.9889 0 Td
(MS)Tj
1.7128 0 Td
(and)Tj
1.8678 0 Td
(better)Tj
2.7511 0 Td
(accuracy)Tj
4.1774 0 Td
(in)Tj
0.9847 0 Td
(latency)Tj
3.3538 0 Td
(studies.)Tj
3.6283 0 Td
(This)Tj
2.0887 0 Td
(could)Tj
2.578 0 Td
(be)Tj
1.3189 0 Td
(applied)Tj
3.3956 0 Td
(to)Tj
-36.6951 -1.468 Td
(assess)Tj
3.3001 0 Td
(visual)Tj
2.7451 0 Td
(cortex)Tj
2.9122 0 Td
(activity)Tj
3.2464 0 Td
(in)Tj
0.9847 0 Td
(MS)Tj
1.7127 0 Td
(diagnosis)Tj
4.3862 0 Td
(and)Tj
1.8679 0 Td
(evolution)Tj
4.1654 0 Td
(studies.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 586.9417 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Introduction)Tj
/F11 1 Tf
0 -1.4976 Td
(MfVEP)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 551.9622 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(The)Tj
1.7801 0 Td
(visual-evoked-potentia)Tj
9.1218 0 Td
(ls)Tj
0.8277 0 Td
(\(VEP\))Tj
2.7213 0 Td
(test)Tj
1.5987 0 Td
(is)Tj
0.8504 0 Td
(a)Tj
0.652 0 Td
(diagnostic)Tj
4.3199 0 Td
(tool)Tj
1.7802 0 Td
(that)Tj
1.7745 0 Td
(allows)Tj
2.6985 0 Td
(an)Tj
1.2076 0 Td
(objective)Tj
3.7814 0 Td
(assessment)Tj
-33.1141 -1.2982 Td
(of)Tj
1.0147 0 Td
(the)Tj
1.4684 0 Td
(visual)Tj
2.5115 0 Td
(pathway.)Tj
3.7927 0 Td
(The)Tj
1.7858 0 Td
(conventional)Tj
5.4255 0 Td
(visual)Tj
2.5115 0 Td
(evoked)Tj
3.05 0 Td
(potential)Tj
3.7644 0 Td
(\(cVEP\))Tj
3.1465 0 Td
(measures)Tj
3.9401 0 Td
(the)Tj
-32.4111 -1.3039 Td
(electrophysiological)Tj
8.1353 0 Td
(signals)Tj
2.9027 0 Td
(obtained)Tj
3.736 0 Td
(by)Tj
1.1792 0 Td
(stimulating)Tj
4.7509 0 Td
(the)Tj
1.474 0 Td
(full)Tj
1.525 0 Td
(visual)Tj
2.5115 0 Td
(field)Tj
1.9729 0 Td
(using)Tj
2.3924 0 Td
(flash)Tj
2.075 0 Td
(or)Tj
1.0998 0 Td
(checker-)Tj
-33.7547 -1.2983 Td
(board)Tj
2.5681 0 Td
(stimuli.)Tj
3.2315 0 Td
(The)Tj
1.7801 0 Td
(cVEP)Tj
2.4662 0 Td
(produces)Tj
3.8777 0 Td
(an)Tj
1.2076 0 Td
(overall)Tj
2.9027 0 Td
(response)Tj
3.7303 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(primary)Tj
3.4526 0 Td
(visual)Tj
2.5115 0 Td
(cortex)Tj
2.7099 0 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(],)Tj
1.6044 0 Td
(but)Tj
1.5477 0 Td
(it)Tj
-36.0961 -1.2983 Td
(does)Tj
2.0352 0 Td
(not)Tj
1.5761 0 Td
(provide)Tj
3.2881 0 Td
(specific)Tj
3.1918 0 Td
(topographical)Tj
5.7373 0 Td
(information)Tj
5.074 0 Td
(about)Tj
2.4945 0 Td
(the)Tj
1.4683 0 Td
(retina)Tj
2.5625 0 Td
(and)Tj
1.7348 0 Td
(visual)Tj
2.5058 0 Td
(cortex)Tj
2.7099 0 Td
([)Tj
0.83 0.64 0.02 0 k
(2)Tj
0 g
(].)Tj
-33.1821 -1.3039 Td
(The)Tj
1.7858 0 Td
(multifocal-visual-evoked-pote)Tj
11.9791 0 Td
(ntials)Tj
2.3754 0 Td
(\(mfVEP\))Tj
3.8268 0 Td
(technique)Tj
4.1669 0 Td
(permits)Tj
3.2825 0 Td
(analysis)Tj
3.3222 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(topo-)Tj
-34.4237 -1.2982 Td
(graphical)Tj
3.9061 0 Td
(features)Tj
3.3448 0 Td
(of)Tj
1.0148 0 Td
(different)Tj
3.6567 0 Td
(sectors)Tj
2.965 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(visual)Tj
2.5115 0 Td
(field)Tj
1.9729 0 Td
(represented)Tj
4.9096 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(visual)Tj
2.5115 0 Td
(cortex)Tj
2.7099 0 Td
([)Tj
0.83 0.64 0.02 0 k
(3)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(4)Tj
0 g
(].)Tj
-34.4917 -1.2983 Td
(Several)Tj
3.05 0 Td
(studies)Tj
2.982 0 Td
([)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
(])Tj
2.3698 0 Td
(have)Tj
2.0579 0 Td
(shown)Tj
2.8517 0 Td
(how)Tj
1.9388 0 Td
(the)Tj
1.4684 0 Td
(mfVEP)Tj
3.1521 0 Td
(technique)Tj
4.1669 0 Td
(overcomes)Tj
4.5127 0 Td
(most)Tj
2.2054 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(limitations)Tj
-33.2388 -1.3039 Td
(of)Tj
1.0147 0 Td
(conventional)Tj
5.4255 0 Td
(VEPs)Tj
2.4038 0 Td
(because)Tj
3.3222 0 Td
(it)Tj
0.7823 0 Td
(allows)Tj
2.6986 0 Td
(for)Tj
1.389 0 Td
(the)Tj
1.4683 0 Td
(simultaneous)Tj
5.5389 0 Td
(recording)Tj
4.1272 0 Td
(of)Tj
1.0148 0 Td
(local)Tj
2.0749 0 Td
(responses)Tj
4.0989 0 Td
(from)Tj
-35.3591 -1.2983 Td
(many)Tj
2.4774 0 Td
(visual)Tj
2.5115 0 Td
(field)Tj
1.9672 0 Td
(sectors)Tj
2.9707 0 Td
(\(up)Tj
1.6044 0 Td
(to)Tj
1.0262 0 Td
(120\).)Tj
-11.3612 -1.2983 Td
(The)Tj
1.7858 0 Td
(mfVEP)Tj
3.1521 0 Td
(technique)Tj
4.1669 0 Td
(has)Tj
1.542 0 Td
(already)Tj
3.1124 0 Td
(been)Tj
2.1203 0 Td
(shown)Tj
2.846 0 Td
(to)Tj
1.0261 0 Td
(be)Tj
1.1509 0 Td
(more)Tj
2.3414 0 Td
(sensitive)Tj
3.6227 0 Td
(than)Tj
2.0296 0 Td
(standard)Tj
3.7247 0 Td
(auto-)Tj
-33.8171 -1.2982 Td
(mated)Tj
2.7212 0 Td
(perimetry)Tj
4.1669 0 Td
(for)Tj
1.389 0 Td
(the)Tj
1.4683 0 Td
(early)Tj
2.1486 0 Td
(detection)Tj
3.9402 0 Td
(of)Tj
1.0148 0 Td
(visual)Tj
2.5058 0 Td
(field)Tj
1.9729 0 Td
(defects)Tj
2.965 0 Td
(in)Tj
1.0375 0 Td
(multiple)Tj
3.5659 0 Td
(sclerosis)Tj
3.5433 0 Td
(\(MS\))Tj
2.2677 0 Td
([)Tj
0.83 0.64 0.02 0 k
(8)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(9)Tj
0 g
(])Tj
-34.7071 -1.3039 Td
(and)Tj
1.7291 0 Td
(other)Tj
2.347 0 Td
(optic)Tj
2.2337 0 Td
(neuropathies,)Tj
5.6523 0 Td
(such)Tj
2.0579 0 Td
(as)Tj
1.0148 0 Td
(glaucoma)Tj
4.0819 0 Td
([)Tj
0.83 0.64 0.02 0 k
(2)Tj
0 g
(].)Tj
-17.9205 -1.2983 Td
(It)Tj
0.8617 0 Td
(is)Tj
0.8447 0 Td
(known)Tj
3.0047 0 Td
(that)Tj
1.7802 0 Td
(the)Tj
1.4683 0 Td
(mfVEP)Tj
3.1521 0 Td
(signal-to-noise)Tj
6.1568 0 Td
(ratio)Tj
2.0976 0 Td
(\(SNR\))Tj
2.7326 0 Td
(is)Tj
0.8504 0 Td
(a)Tj
0.652 0 Td
(significant)Tj
4.388 0 Td
(limiting)Tj
3.4015 0 Td
(factor)Tj
2.5399 0 Td
(for)Tj
-35.1267 -1.2983 Td
(further)Tj
3.0273 0 Td
(development)Tj
5.4085 0 Td
(of)Tj
1.0148 0 Td
(clinical)Tj
3.0784 0 Td
(application)Tj
4.6771 0 Td
(of)Tj
1.0148 0 Td
(mfVEPs,)Tj
3.7417 0 Td
(mainly)Tj
2.9877 0 Td
(because)Tj
3.3222 0 Td
(the)Tj
1.4684 0 Td
(amplitudes)Tj
4.6431 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
-35.3988 -1.3039 Td
(signal)Tj
2.5398 0 Td
(recorded)Tj
3.7984 0 Td
(are)Tj
1.4456 0 Td
(very)Tj
1.9276 0 Td
(small)Tj
2.3244 0 Td
(compared)Tj
4.2463 0 Td
(with)Tj
1.9955 0 Td
(cVEP.)Tj
-17.0814 -1.2982 Td
(In)Tj
1.1111 0 Td
(this)Tj
1.6725 0 Td
(context,)Tj
3.4129 0 Td
(various)Tj
3.1407 0 Td
(studies)Tj
2.9877 0 Td
(have)Tj
2.058 0 Td
(attempted)Tj
4.2632 0 Td
(to)Tj
1.0262 0 Td
(improve)Tj
3.5773 0 Td
(the)Tj
1.4683 0 Td
(diagnostic)Tj
4.32 0 Td
(capacity)Tj
3.4752 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
-34.7241 -1.2983 Td
(mfVEP)Tj
3.1521 0 Td
(technique)Tj
4.1669 0 Td
(either)Tj
2.5284 0 Td
(by)Tj
1.1793 0 Td
(enhancing)Tj
4.4106 0 Td
(the)Tj
1.4684 0 Td
(visual)Tj
2.5115 0 Td
(stimulus)Tj
3.6283 0 Td
(parameters)Tj
4.6714 0 Td
([)Tj
0.83 0.64 0.02 0 k
(10)Tj
0 g
(],)Tj
2.0807 0 Td
(by)Tj
1.1792 0 Td
(altering)Tj
3.2768 0 Td
(the)Tj
-34.2536 -1.3039 Td
(number)Tj
3.4185 0 Td
(of)Tj
1.0148 0 Td
(electrodes)Tj
4.2236 0 Td
(used)Tj
2.0579 0 Td
(and)Tj
1.7348 0 Td
(their)Tj
2.1033 0 Td
(localization,)Tj
5.04 0 Td
(by)Tj
1.1792 0 Td
(adding)Tj
2.9934 0 Td
(virtual)Tj
2.8176 0 Td
(channels)Tj
3.736 0 Td
([)Tj
0.83 0.64 0.02 0 k
(11)Tj
0 g
(],)Tj
2.075 0 Td
(by)Tj
1.1792 0 Td
(investi-)Tj
-33.5733 -1.2983 Td
(gating)Tj
2.6985 0 Td
(offline)Tj
2.7893 0 Td
(signal)Tj
2.5398 0 Td
(processing)Tj
4.4674 0 Td
(methods)Tj
3.685 0 Td
(such)Tj
2.0579 0 Td
(as)Tj
1.0148 0 Td
(principal)Tj
3.8098 0 Td
(component)Tj
4.8132 0 Td
(analysis)Tj
3.3278 0 Td
([)Tj
0.83 0.64 0.02 0 k
(12)Tj
0 g
(],)Tj
2.075 0 Td
(by)Tj
1.1849 0 Td
(using)Tj
-34.4634 -1.2983 Td
(wavelets)Tj
3.5432 0 Td
([)Tj
0.83 0.64 0.02 0 k
(13)Tj
0 g
(])Tj
1.8539 0 Td
(or)Tj
1.0941 0 Td
(by)Tj
1.1849 0 Td
(applying)Tj
3.668 0 Td
(Prony's)Tj
3.2372 0 Td
(method)Tj
3.3222 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
0.6576 0 Td
(filter)Tj
2.1146 0 Td
([)Tj
0.83 0.64 0.02 0 k
(14)Tj
0 g
(].)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 256.0251 cm
BT
/F11 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(MfVEP)Tj
3.3118 0 Td
(analysis)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 239.0173 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Amplitude)Tj
4.5297 0 Td
(and)Tj
1.7291 0 Td
(latency)Tj
3.0501 0 Td
(are)Tj
1.4513 0 Td
(the)Tj
1.4683 0 Td
(mfVEP)Tj
3.1521 0 Td
(signal)Tj
2.5399 0 Td
(parameters)Tj
4.6714 0 Td
(most)Tj
2.211 0 Td
(frequently)Tj
4.3087 0 Td
(used)Tj
2.0579 0 Td
(in)Tj
1.0375 0 Td
(clinical)Tj
3.0727 0 Td
(anal-)Tj
-35.2797 -1.3039 Td
(ysis.)Tj
1.8878 0 Td
(MfVEP)Tj
3.2258 0 Td
(signal)Tj
2.5398 0 Td
(amplitude)Tj
4.2803 0 Td
(can)Tj
1.6271 0 Td
(be)Tj
1.1509 0 Td
(calculated)Tj
4.2066 0 Td
(using)Tj
2.3867 0 Td
(the)Tj
1.4683 0 Td
(difference)Tj
4.2066 0 Td
(between)Tj
3.5263 0 Td
(the)Tj
1.474 0 Td
(positive)Tj
3.3165 0 Td
(peak)Tj
-35.2967 -1.2982 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4683 0 Td
(negative)Tj
3.5376 0 Td
(trough)Tj
2.914 0 Td
(\(peak-to-trough)Tj
6.6387 0 Td
(or)Tj
1.0942 0 Td
(P2T\).)Tj
2.4321 0 Td
(P2T)Tj
1.8652 0 Td
(has)Tj
1.542 0 Td
(the)Tj
1.474 0 Td
(advantage)Tj
4.2406 0 Td
(of)Tj
1.0148 0 Td
(being)Tj
2.4265 0 Td
(a)Tj
0.6576 0 Td
(quantifi-)Tj
-33.0347 -1.2983 Td
(able)Tj
1.8311 0 Td
(output)Tj
2.897 0 Td
(value)Tj
2.3017 0 Td
(\(measured)Tj
4.4504 0 Td
(in)Tj
1.0375 0 Td
(volts\))Tj
2.4264 0 Td
([)Tj
0.83 0.64 0.02 0 k
(13)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(15)Tj
0 g
(].)Tj
3.2542 0 Td
(P2T)Tj
1.8651 0 Td
(amplitude)Tj
4.2803 0 Td
(decline)Tj
3.0784 0 Td
(is)Tj
0.8504 0 Td
(proportional)Tj
5.3121 0 Td
(to)Tj
1.0262 0 Td
(the)Tj
1.4683 0 Td
(risk)Tj
-36.0791 -1.3039 Td
(of)Tj
1.0147 0 Td
(MS)Tj
1.5874 0 Td
([)Tj
0.83 0.64 0.02 0 k
(16)Tj
0 g
(].)Tj
2.075 0 Td
(Moreover,)Tj
4.3993 0 Td
(an)Tj
1.2019 0 Td
(inverse)Tj
3.0671 0 Td
(relationship)Tj
4.9889 0 Td
(was)Tj
1.7008 0 Td
(found)Tj
2.6192 0 Td
(between)Tj
3.5263 0 Td
(retinal)Tj
2.8119 0 Td
(nerve)Tj
2.4435 0 Td
(fiber)Tj
2.0749 0 Td
(layer)Tj
-33.5109 -1.2983 Td
(thicknessas)Tj
5.6465 0 Td
(measured)Tj
4.1046 0 Td
(by)Tj
1.1848 0 Td
(optical)Tj
2.914 0 Td
(coherence)Tj
4.2917 0 Td
(topographyand)Tj
7.2509 0 Td
(P2T)Tj
1.8652 0 Td
([)Tj
0.83 0.64 0.02 0 k
(15)Tj
0 g
(].)Tj
-26.0615 -1.2982 Td
(MfVEP)Tj
3.2258 0 Td
(latency)Tj
3.05 0 Td
(is)Tj
0.8447 0 Td
(measured)Tj
4.1103 0 Td
(as)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(delayed)Tj
3.2598 0 Td
(conduction)Tj
4.7962 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(visual)Tj
2.5115 0 Td
(stimulus)Tj
3.6283 0 Td
(from)Tj
2.2054 0 Td
(the)Tj
-33.8001 -1.2983 Td
(moment)Tj
3.6339 0 Td
(it)Tj
0.7881 0 Td
(is)Tj
0.8447 0 Td
(presented)Tj
4.1159 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.4683 0 Td
(screen)Tj
2.7723 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4683 0 Td
(instant)Tj
2.9764 0 Td
(it)Tj
0.788 0 Td
(is)Tj
0.8447 0 Td
(elicited)Tj
3.1011 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(visual)Tj
2.5058 0 Td
(cortex.)Tj
2.9367 0 Td
(Interocular)Tj
-33.0517 -1.3039 Td
(\(IO\))Tj
1.9785 0 Td
(latency)Tj
3.0387 0 Td
(is)Tj
0.8391 0 Td
(defined)Tj
3.2145 0 Td
(as)Tj
1.0091 0 Td
(the)Tj
1.457 0 Td
(difference)Tj
4.2009 0 Td
(between)Tj
3.5149 0 Td
(the)Tj
1.4627 0 Td
(response)Tj
3.7247 0 Td
(latencies)Tj
3.634 0 Td
(of)Tj
1.0091 0 Td
(both)Tj
2.0523 0 Td
(eyes)Tj
1.8709 0 Td
(and)Tj
1.7234 0 Td
(is)Tj
0.8391 0 Td
(mea-)Tj
-35.5689 -1.2983 Td
(sured)Tj
2.4321 0 Td
(as)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(subtraction)Tj
4.7622 0 Td
(between)Tj
3.5319 0 Td
(the)Tj
1.4684 0 Td
(second-highest)Tj
6.2305 0 Td
(peak)Tj
2.0919 0 Td
(implicit)Tj
3.3279 0 Td
(time)Tj
2.0239 0 Td
([)Tj
0.83 0.64 0.02 0 k
(17)Tj
0 g
(])Tj
1.8538 0 Td
(or)Tj
1.0999 0 Td
(as)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(temporal)Tj
-33.7887 -1.2983 Td
(shift)Tj
1.9615 0 Td
(producing)Tj
4.3767 0 Td
(the)Tj
1.4683 0 Td
(best)Tj
1.8085 0 Td
(cross-correlation)Tj
6.9902 0 Td
(value)Tj
2.3074 0 Td
([)Tj
0.83 0.64 0.02 0 k
(18)Tj
0 g
(].)Tj
-17.7164 -1.3039 Td
(Delays)Tj
2.8799 0 Td
(in)Tj
1.0318 0 Td
(mfVEP)Tj
3.1522 0 Td
(latency)Tj
3.05 0 Td
(signals)Tj
2.9027 0 Td
(are)Tj
1.4456 0 Td
(usually)Tj
3.0217 0 Td
(observed)Tj
3.7928 0 Td
(after)Tj
2.0352 0 Td
(an)Tj
1.2019 0 Td
(optic)Tj
2.2337 0 Td
(neuritis)Tj
3.2882 0 Td
(\(ON\))Tj
2.3811 0 Td
(episode,)Tj
-33.613 -1.2982 Td
(reflecting)Tj
3.9741 0 Td
(optic)Tj
2.2337 0 Td
(nerve)Tj
2.4434 0 Td
(fiber)Tj
2.075 0 Td
(demyelination,)Tj
6.2135 0 Td
(whereas)Tj
3.4412 0 Td
(shortening)Tj
4.5411 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(latency)Tj
3.0501 0 Td
(represents)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 385.285 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(EMD)Tj
2.4165 0 Td
(processing)Tj
4.9678 0 Td
(to)Tj
1.0417 0 Td
(improve)Tj
3.7134 0 Td
(mfVEP)Tj
3.3024 0 Td
(in)Tj
0.978 0 Td
(multiple)Tj
3.6 0 Td
(sclerosis)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.01949)Tj
4.089 0 Td
(64)Tj
0 g
2.0906 0 Td
(April)Tj
2.1827 0 Td
(20,)Tj
1.5874 0 Td
(2018)Tj
35.1357 0 Td
(2)Tj
0.7654 0 Td
(/)Tj
0.496 0 Td
(17)Tj
/F9 1 Tf
-0.025 Tc
-66.402 84.0904 Td
(data)Tj
1.7929 0 Td
(collection)Tj
3.7347 0 Td
(and)Tj
1.5945 0 Td
(analysis)Tj
2.9622 0 Td
(,)Tj
0.4464 0 Td
(decision)Tj
3.2883 0 Td
(to)Tj
0.9496 0 Td
(publish,)Tj
3.1465 0 Td
(or)Tj
-17.9151 -1.3748 Td
(preparation)Tj
4.4433 0 Td
(of)Tj
0.9496 0 Td
(the)Tj
1.3677 0 Td
(manuscript.)Tj
/F8 1 Tf
-6.7606 -2.126 Td
(Competing)Tj
4.3795 0 Td
(interests)Tj
3.3307 0 Td
(:)Tj
/F9 1 Tf
0.4819 0 Td
(The)Tj
1.5875 0 Td
(authors)Tj
3.0401 0 Td
(have)Tj
1.963 0 Td
(declared)Tj
-14.7827 -1.3749 Td
(that)Tj
1.6228 0 Td
(no)Tj
1.1693 0 Td
(competing)Tj
4.1599 0 Td
(interests)Tj
ET
endstream
endobj
38 0 obj
<>stream
endstream
endobj
39 0 obj
<>stream
endstream
endobj
40 0 obj
<>stream
endstream
endobj
41 0 obj
<>stream
endstream
endobj
42 0 obj
<>stream
endstream
endobj
43 0 obj
<>stream
endstream
endobj
44 0 obj
<>stream
endstream
endobj
45 0 obj
<>stream
endstream
endobj
46 0 obj
<>stream
endstream
endobj
47 0 obj
<>stream
endstream
endobj
48 0 obj
<>stream
endstream
endobj
49 0 obj
<>stream
endstream
endobj
50 0 obj
<>stream
endstream
endobj
51 0 obj
<>stream
endstream
endobj
52 0 obj
<>stream
endstream
endobj
53 0 obj
<>stream
endstream
endobj
54 0 obj
<>stream
endstream
endobj
55 0 obj
<>stream
endstream
endobj
56 0 obj
<>stream
endstream
endobj
57 0 obj
<>stream
BT
10.3394 79.2147 Td
(exist.)Tj
ET
Q
endstream
endobj
58 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 61 0 R/Contents 62 0 R/TrimBox[0 0 612 792]>>
endobj
61 0 obj
[63 0 R 64 0 R 65 0 R 66 0 R 67 0 R 68 0 R 69 0 R 70 0 R 71 0 R 72 0 R 73 0 R 74 0 R 75 0 R 76 0 R 77 0 R 78 0 R 79 0 R]
endobj
63 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194964.ref019)>>
endobj
64 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194964.ref020)>>
endobj
65 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194964.ref021)>>
endobj
66 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194964.ref022)>>
endobj
67 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194964.ref023)>>
endobj
68 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194964.ref024)>>
endobj
69 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194964.ref025)>>
endobj
70 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194964.ref026)>>
endobj
71 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194964.ref027)>>
endobj
72 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194964.ref028)>>
endobj
73 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194964.ref029)>>
endobj
74 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194964.ref030)>>
endobj
75 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194964.ref025)>>
endobj
76 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194964.ref031)>>
endobj
77 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194964.ref032)>>
endobj
78 0 obj
<>/Border[0 0 0]/Dest(Rpone.0194964.ref033)>>
endobj
79 0 obj
<>/Border[0 0 0]/A 80 0 R>>
endobj
80 0 obj
<>
endobj
62 0 obj
[81 0 R 82 0 R 83 0 R 84 0 R 85 0 R 86 0 R 87 0 R 88 0 R 89 0 R 90 0 R 91 0 R 92 0 R 93 0 R 94 0 R 95 0 R 96 0 R 97 0 R 98 0 R]
endobj
81 0 obj
<>stream
q
0.83 0.64 0.02 0 k
301.3795 706.337 m
310.9039 706.337 l
h
f*
313.1717 706.337 m
322.6394 706.337 l
h
f*
438.8598 641.1402 m
448.3276 641.1402 l
h
f*
327.685 563.1307 m
337.2094 563.1307 l
h
f*
526.0535 511.1433 m
535.578 511.1433 l
h
f*
238.2236 459.0992 m
247.748 459.0992 l
h
f*
250.0157 459.0992 m
259.4835 459.0992 l
h
f*
476.1071 420.0945 m
485.6315 420.0945 l
h
f*
470.8913 407.1118 m
480.4157 407.1118 l
h
f*
203.4142 394.1291 m
212.9386 394.1291 l
h
f*
548.9008 394.1291 m
558.4252 394.1291 l
h
f*
263.8488 381.1465 m
273.3732 381.1465 l
h
f*
283.1811 355.1244 m
292.7055 355.1244 l
h
f*
411.5906 342.1417 m
421.115 342.1417 l
h
f*
305.6315 172.9134 m
315.0992 172.9134 l
h
f*
265.2094 133.9087 m
274.7339 133.9087 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(remyelination)Tj
5.8279 0 Td
(processes)Tj
3.9685 0 Td
([)Tj
0.83 0.64 0.02 0 k
(19)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(20)Tj
0 g
(].)Tj
3.2542 0 Td
(Interocular)Tj
4.7111 0 Td
(latency)Tj
3.0501 0 Td
(measurements)Tj
6.0321 0 Td
(are)Tj
1.4456 0 Td
(especially)Tj
4.0195 0 Td
(useful)Tj
2.5909 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
-35.9374 -1.3039 Td
(case)Tj
1.8595 0 Td
(of)Tj
1.0148 0 Td
(unilateral)Tj
4.0195 0 Td
(ON)Tj
1.7007 0 Td
(because)Tj
3.3222 0 Td
(a)Tj
0.652 0 Td
(normal)Tj
3.1464 0 Td
(contralateral)Tj
5.2554 0 Td
(eye)Tj
1.5251 0 Td
(serves)Tj
2.6135 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
0.6519 0 Td
(good)Tj
2.2281 0 Td
(control)Tj
3.1237 0 Td
(reference.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 659.2251 cm
BT
/F11 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Empirical)Tj
4.3323 0 Td
(mode)Tj
2.5559 0 Td
(decomposition)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 642.2173 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Empirical)Tj
4.1328 0 Td
(mode)Tj
2.5002 0 Td
(decomposition)Tj
6.1908 0 Td
(\(EMD\))Tj
3.1011 0 Td
(has)Tj
1.542 0 Td
(been)Tj
2.126 0 Td
(proposed)Tj
3.9515 0 Td
([)Tj
0.83 0.64 0.02 0 k
(21)Tj
0 g
(])Tj
1.8481 0 Td
(as)Tj
1.0148 0 Td
(an)Tj
1.2019 0 Td
(adaptive)Tj
3.5773 0 Td
(timefrequency)Tj
-31.1865 -1.3039 Td
(data)Tj
1.9105 0 Td
(analysis)Tj
3.3278 0 Td
(method.)Tj
3.549 0 Td
(This)Tj
1.9899 0 Td
(method)Tj
3.3222 0 Td
(decomposes)Tj
5.091 0 Td
(a)Tj
0.6519 0 Td
(signal)Tj
2.5455 0 Td
(into)Tj
1.8369 0 Td
(a)Tj
0.6576 0 Td
(sum)Tj
1.9276 0 Td
(of)Tj
1.0148 0 Td
(oscillatory)Tj
4.3369 0 Td
(modes)Tj
-32.1616 -1.2982 Td
(\(IMF)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 220.9889 614.5511 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 224.5606 616.1952 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(,)Tj
0.4478 0 Td
(IMF)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 246.6141 614.5511 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 250.1858 616.1952 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(,)Tj
/F12 1 Tf
0 Tc
0.4422 0 Td
(.)Tj
0.4365 0 Td
(.)Tj
0.4308 0 Td
(.)Tj
/F6 1 Tf
-0.004 Tc
(\),)Tj
1.0602 0 Td
(called)Tj
2.5228 0 Td
(intrinsic)Tj
3.5716 0 Td
(mode)Tj
2.4945 0 Td
(functions)Tj
3.9912 0 Td
(\(IMFs\),)Tj
3.2485 0 Td
(which)Tj
2.6475 0 Td
(represent)Tj
3.9571 0 Td
(fast)Tj
1.6044 0 Td
(to)Tj
1.0262 0 Td
(slow)Tj
2.0182 0 Td
(oscilla-)Tj
-34.4689 -1.2982 Td
(tions)Tj
2.1996 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(signal.)Tj
-3.5092 -1.3039 Td
(The)Tj
1.7858 0 Td
(method)Tj
3.3221 0 Td
(successively)Tj
4.9492 0 Td
(obtains)Tj
3.1408 0 Td
(the)Tj
1.4683 0 Td
(highest)Tj
3.0954 0 Td
(frequencies)Tj
4.7792 0 Td
(\(IMF)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 458.4188 588.5291 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 461.9905 590.1732 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(,)Tj
0.4422 0 Td
(IMF)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 484.044 588.5291 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 487.6157 590.1732 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(,)Tj
/F12 1 Tf
0 Tc
0.4422 0 Td
(.)Tj
0.4365 0 Td
(.)Tj
0.4308 0 Td
(.)Tj
/F6 1 Tf
-0.004 Tc
(\))Tj
0.8334 0 Td
(from)Tj
2.2054 0 Td
(a)Tj
0.6519 0 Td
(signal,)Tj
2.7666 0 Td
(so)Tj
-36.5269 -1.2982 Td
(it)Tj
0.7824 0 Td
(is)Tj
0.8504 0 Td
(equivalent)Tj
4.3483 0 Td
(to)Tj
1.0261 0 Td
(a)Tj
0.652 0 Td
(bank)Tj
2.211 0 Td
(of)Tj
1.0148 0 Td
(filters)Tj
2.4718 0 Td
(of)Tj
1.0148 0 Td
(overlapping)Tj
4.9719 0 Td
(frequency)Tj
4.1896 0 Td
(content.)Tj
3.4923 0 Td
(In)Tj
1.1111 0 Td
(the)Tj
1.4683 0 Td
(electroencephalog-)Tj
-29.6048 -1.2983 Td
(raphy)Tj
2.5228 0 Td
(\(EEG\))Tj
2.7553 0 Td
(field,)Tj
2.1997 0 Td
(in)Tj
1.0318 0 Td
(reference)Tj
3.9174 0 Td
([)Tj
0.83 0.64 0.02 0 k
(22)Tj
0 g
(])Tj
1.8539 0 Td
(the)Tj
1.4683 0 Td
(authors)Tj
3.2485 0 Td
(demonstrated)Tj
5.76 0 Td
(that)Tj
1.7801 0 Td
(IMF)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 482.9669 562.507 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 488.7496 564.2078 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(represents)Tj
4.3199 0 Td
(the)Tj
-33.1934 -1.2982 Td
(gamma)Tj
3.1918 0 Td
(band)Tj
2.2394 0 Td
(neuronal)Tj
3.8267 0 Td
(oscillation)Tj
4.3257 0 Td
(\()Tj
/F13 1 Tf
0 Tc
(>)Tj
/F6 1 Tf
-0.004 Tc
(30)Tj
2.279 0 Td
(Hz\),)Tj
1.9672 0 Td
(IMF)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 395.9433 549.5244 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 401.6692 551.2251 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(represents)Tj
4.3199 0 Td
(beta)Tj
1.8822 0 Td
(band)Tj
2.2394 0 Td
(oscillation)Tj
4.3256 0 Td
(\(1330)Tj
-32.9326 -1.3039 Td
(Hz\),)Tj
1.9672 0 Td
(IMF)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 237.2598 536.5417 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(3)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 243.0425 538.1858 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(represents)Tj
4.3199 0 Td
(the)Tj
1.4684 0 Td
(alpha)Tj
2.3754 0 Td
(band)Tj
2.2393 0 Td
(oscillation)Tj
4.3257 0 Td
(\(813)Tj
2.5058 0 Td
(Hz\),)Tj
1.9672 0 Td
(IMF)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 452.6362 536.5417 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(4)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 458.4188 538.1858 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(represents)Tj
4.3199 0 Td
(the)Tj
1.4684 0 Td
(delta)Tj
2.1486 0 Td
(band)Tj
-33.7773 -1.2982 Td
(\(3.58)Tj
2.7269 0 Td
(Hz\))Tj
1.7405 0 Td
(oscillation,)Tj
4.5524 0 Td
(and)Tj
1.7291 0 Td
(IMF)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 325.1338 523.559 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(5)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 330.8598 525.2031 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(and)Tj
1.7347 0 Td
(IMF)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 365.7826 523.559 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(6)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 371.5653 525.2031 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(represent)Tj
3.9571 0 Td
(the)Tj
1.4683 0 Td
(theta)Tj
2.2054 0 Td
(band)Tj
2.2337 0 Td
(oscillation)Tj
4.3256 0 Td
(\(0.53.5)Tj
3.4299 0 Td
(Hz\).)Tj
-33.5789 -1.2982 Td
(Typical)Tj
3.1748 0 Td
(advanced)Tj
3.9968 0 Td
(methods)Tj
3.685 0 Td
(used)Tj
2.058 0 Td
(to)Tj
1.0261 0 Td
(process)Tj
3.186 0 Td
(biomedical)Tj
4.6431 0 Td
(signals)Tj
2.9027 0 Td
(include)Tj
3.1804 0 Td
(Fourier)Tj
3.2145 0 Td
([)Tj
0.83 0.64 0.02 0 k
(23)Tj
0 g
(])Tj
1.8539 0 Td
(and)Tj
-34.1175 -1.3039 Td
(wavelet)Tj
3.1748 0 Td
(analysis.)Tj
3.5433 0 Td
(These)Tj
2.5568 0 Td
(two)Tj
1.7064 0 Td
(methods)Tj
3.6737 0 Td
(need)Tj
2.1373 0 Td
(some)Tj
2.3186 0 Td
(predefined)Tj
4.5298 0 Td
(basis)Tj
2.143 0 Td
(functions)Tj
3.9854 0 Td
(to)Tj
1.0148 0 Td
(decompose)Tj
4.7225 0 Td
(a)Tj
0.6463 0 Td
(sig-)Tj
-36.1527 -1.2983 Td
(nal.)Tj
1.6724 0 Td
(In)Tj
1.1112 0 Td
(contrast,)Tj
3.685 0 Td
(the)Tj
1.4683 0 Td
(EMD)Tj
2.4208 0 Td
(method)Tj
3.3222 0 Td
(does)Tj
2.0409 0 Td
(not)Tj
1.5703 0 Td
(require)Tj
3.1124 0 Td
(a)Tj
0.6577 0 Td
(prior)Tj
2.2507 0 Td
(known)Tj
3.0047 0 Td
(basis.)Tj
2.3754 0 Td
(Comparisons)Tj
5.5785 0 Td
(with)Tj
-34.2705 -1.2983 Td
(Fourier)Tj
3.2145 0 Td
(and)Tj
1.7291 0 Td
(wavelet)Tj
3.1861 0 Td
(analyses)Tj
3.4809 0 Td
(show)Tj
2.3017 0 Td
(that)Tj
1.7802 0 Td
(EMD)Tj
2.415 0 Td
(obtains)Tj
3.1408 0 Td
(much)Tj
2.5228 0 Td
(better)Tj
2.5398 0 Td
(temporal)Tj
3.8381 0 Td
(and)Tj
1.7291 0 Td
(frequency)Tj
4.1896 0 Td
(res-)Tj
-36.0677 -1.3039 Td
(olutions)Tj
3.4809 0 Td
([)Tj
0.83 0.64 0.02 0 k
(24)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(25)Tj
0 g
(].)Tj
-2.2847 -1.2982 Td
(EMD)Tj
2.4208 0 Td
(has)Tj
1.542 0 Td
(been)Tj
2.126 0 Td
(applied)Tj
3.1521 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4684 0 Td
(study)Tj
2.3867 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4682 0 Td
(non-linear)Tj
4.4674 0 Td
(and)Tj
1.7291 0 Td
(non-stationary)Tj
6.1512 0 Td
(properties)Tj
4.2746 0 Td
(of)Tj
1.0148 0 Td
(time)Tj
-35.4384 -1.2983 Td
(series)Tj
2.4264 0 Td
(and)Tj
1.7291 0 Td
(has)Tj
1.5421 0 Td
(been)Tj
2.126 0 Td
(shown)Tj
2.8459 0 Td
(to)Tj
1.0262 0 Td
(be)Tj
1.1508 0 Td
(a)Tj
0.652 0 Td
(reliable)Tj
3.1407 0 Td
(and)Tj
1.7291 0 Td
(effective)Tj
3.5092 0 Td
(method)Tj
3.3222 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(processing)Tj
4.4674 0 Td
(of)Tj
1.0148 0 Td
(different)Tj
-33.1877 -1.3039 Td
(biomedical)Tj
4.6431 0 Td
(engineering)Tj
4.9719 0 Td
(signals:)Tj
3.1295 0 Td
(enhanced)Tj
4.0762 0 Td
(ECG)Tj
2.1655 0 Td
(to)Tj
1.0262 0 Td
(detect)Tj
2.6135 0 Td
(QRS)Tj
2.0636 0 Td
(waves)Tj
2.5795 0 Td
([)Tj
0.83 0.64 0.02 0 k
(26)Tj
0 g
(],)Tj
2.0749 0 Td
(detection)Tj
3.9402 0 Td
(of)Tj
1.0148 0 Td
(compo-)Tj
-34.2989 -1.2983 Td
(nents)Tj
2.3981 0 Td
(that)Tj
1.7801 0 Td
(might)Tj
2.5965 0 Td
(be)Tj
1.1509 0 Td
(related)Tj
2.9423 0 Td
(to)Tj
1.0262 0 Td
(phoneme)Tj
3.9911 0 Td
(representation)Tj
6.0093 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4684 0 Td
(brain)Tj
2.347 0 Td
([)Tj
0.83 0.64 0.02 0 k
(27)Tj
0 g
(],)Tj
2.0806 0 Td
(EEG)Tj
2.075 0 Td
(artifact)Tj
3.033 0 Td
(removal)Tj
-33.936 -1.2983 Td
([)Tj
0.83 0.64 0.02 0 k
(28)Tj
0 g
(],)Tj
2.0749 0 Td
(and)Tj
1.7292 0 Td
(detection)Tj
3.9401 0 Td
(and)Tj
1.7291 0 Td
(classification)Tj
5.3461 0 Td
(of)Tj
1.0148 0 Td
(retinal)Tj
2.8119 0 Td
(diseases)Tj
3.3732 0 Td
(from)Tj
2.211 0 Td
(electroretinogram)Tj
7.4154 0 Td
(signals)Tj
2.9026 0 Td
([)Tj
0.83 0.64 0.02 0 k
(29)Tj
0 g
(].)Tj
-34.5483 -1.2982 Td
(The)Tj
1.7801 0 Td
(authors)Tj
3.2485 0 Td
(of)Tj
1.0148 0 Td
([)Tj
0.83 0.64 0.02 0 k
(30)Tj
0 g
(])Tj
1.8482 0 Td
(used)Tj
2.0636 0 Td
(EMD)Tj
2.4151 0 Td
(to)Tj
1.0261 0 Td
(analyze)Tj
3.1748 0 Td
(the)Tj
1.4683 0 Td
(neuronal)Tj
3.8267 0 Td
(activity)Tj
3.1181 0 Td
(of)Tj
1.0148 0 Td
(a)Tj
0.6576 0 Td
(macaque)Tj
3.7871 0 Td
(V4)Tj
1.389 0 Td
(visual)Tj
2.5114 0 Td
(cortex)Tj
-34.3442 -1.3039 Td
(area,)Tj
2.1089 0 Td
(showing)Tj
3.5773 0 Td
(that)Tj
1.7802 0 Td
(evoked)Tj
3.0501 0 Td
(potentials)Tj
4.1215 0 Td
(can)Tj
1.6271 0 Td
(be)Tj
1.1507 0 Td
(resolved)Tj
3.5377 0 Td
(into)Tj
1.8368 0 Td
(a)Tj
0.6576 0 Td
(sum)Tj
1.9276 0 Td
(of)Tj
1.0148 0 Td
(intrinsic)Tj
3.5716 0 Td
(components;)Tj
5.3971 0 Td
(in)Tj
1.0375 0 Td
(a)Tj
-36.3965 -1.2983 Td
(similar)Tj
2.9763 0 Td
(experiment,)Tj
5.0003 0 Td
([)Tj
0.83 0.64 0.02 0 k
(25)Tj
0 g
(])Tj
1.8425 0 Td
(showed)Tj
3.2485 0 Td
(that)Tj
1.7688 0 Td
(EMD)Tj
2.415 0 Td
(may)Tj
1.9219 0 Td
(offer)Tj
2.092 0 Td
(better)Tj
2.5341 0 Td
(temporal)Tj
3.8324 0 Td
(and)Tj
1.7235 0 Td
(frequency)Tj
4.1839 0 Td
(resolution)Tj
-33.5392 -1.2983 Td
(in)Tj
1.0318 0 Td
(comparison)Tj
4.9776 0 Td
(with)Tj
2.0012 0 Td
(Fourier)Tj
3.2145 0 Td
(analysis.)Tj
3.549 0 Td
(The)Tj
1.7858 0 Td
(authors)Tj
3.2427 0 Td
(of)Tj
1.0148 0 Td
([)Tj
0.83 0.64 0.02 0 k
(31)Tj
0 g
(])Tj
1.8538 0 Td
(used)Tj
2.058 0 Td
(EMD)Tj
2.4207 0 Td
(to)Tj
1.0262 0 Td
(separate)Tj
3.4809 0 Td
(EEG)Tj
2.075 0 Td
(compo-)Tj
-33.732 -1.3039 Td
(nents)Tj
2.3981 0 Td
(and)Tj
1.7291 0 Td
(detect)Tj
2.6192 0 Td
(VEPs)Tj
2.4038 0 Td
(in)Tj
1.0318 0 Td
(EEG)Tj
2.0749 0 Td
(signals.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 294.9732 cm
BT
/F11 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Aim)Tj
2.0504 0 Td
(of)Tj
1.0677 0 Td
(this)Tj
1.7764 0 Td
(work)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 278.022 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(The)Tj
1.7801 0 Td
(aim)Tj
1.7405 0 Td
(of)Tj
1.0148 0 Td
(this)Tj
1.6781 0 Td
(work)Tj
2.2733 0 Td
(was)Tj
1.7008 0 Td
(to)Tj
1.0261 0 Td
(test,)Tj
1.8255 0 Td
(for)Tj
1.389 0 Td
(the)Tj
1.4683 0 Td
(first)Tj
1.8029 0 Td
(time,)Tj
2.2563 0 Td
(application)Tj
4.6828 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(EMD)Tj
2.4151 0 Td
(preprocessing)Tj
-29.5368 -1.3039 Td
(method)Tj
3.3221 0 Td
(to)Tj
1.0262 0 Td
(mfVEP)Tj
3.1521 0 Td
(signals)Tj
2.9026 0 Td
(to)Tj
1.0262 0 Td
(improve)Tj
3.5773 0 Td
(MS)Tj
1.5874 0 Td
(diagnosis.)Tj
-15.3977 -1.2982 Td
(For)Tj
1.627 0 Td
(this)Tj
1.6781 0 Td
(purpose,)Tj
3.668 0 Td
(two)Tj
1.7122 0 Td
(experiments)Tj
5.1363 0 Td
(were)Tj
2.1203 0 Td
(proposed:)Tj
4.1783 0 Td
(a\))Tj
0.9977 0 Td
(evaluation)Tj
4.3597 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(ability)Tj
2.6929 0 Td
(to)Tj
1.0262 0 Td
(discrimi-)Tj
-32.876 -1.2983 Td
(nate)Tj
1.9218 0 Td
(between)Tj
3.532 0 Td
(mfVEP)Tj
3.1464 0 Td
(signals)Tj
2.9027 0 Td
(recorded)Tj
3.7984 0 Td
(from)Tj
2.2053 0 Td
(subjects)Tj
3.3789 0 Td
(with)Tj
1.9956 0 Td
(different)Tj
3.6566 0 Td
(degrees)Tj
3.2145 0 Td
(of)Tj
1.0148 0 Td
(MS)Tj
1.5931 0 Td
(affectation)Tj
-32.3601 -1.3039 Td
(by)Tj
1.1792 0 Td
(using)Tj
2.3924 0 Td
(the)Tj
1.4683 0 Td
(amplitude)Tj
4.2803 0 Td
(and)Tj
1.7291 0 Td
(b\))Tj
1.0715 0 Td
(study)Tj
2.3868 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(variability)Tj
4.2236 0 Td
(of)Tj
1.0148 0 Td
(interocular)Tj
4.6375 0 Td
(latency)Tj
3.05 0 Td
(in)Tj
1.0375 0 Td
(control)Tj
3.1181 0 Td
(subjects.)Tj
-32.876 -1.2983 Td
(In)Tj
1.1111 0 Td
(the)Tj
1.4684 0 Td
(first)Tj
1.8085 0 Td
(experiment,)Tj
5.0003 0 Td
(we)Tj
1.3266 0 Td
(aimed)Tj
2.6929 0 Td
(to)Tj
1.0261 0 Td
(examine)Tj
3.6 0 Td
(how)Tj
1.9389 0 Td
(the)Tj
1.474 0 Td
(amplitude,)Tj
4.507 0 Td
(quantified)Tj
4.3086 0 Td
(as)Tj
1.0148 0 Td
(P2T,)Tj
2.092 0 Td
(of)Tj
1.0148 0 Td
(orig-)Tj
-35.5802 -1.2982 Td
(inal)Tj
1.7121 0 Td
(and)Tj
1.7348 0 Td
(EMD-processed)Tj
6.684 0 Td
(mfVEP)Tj
3.1464 0 Td
(signals)Tj
2.9084 0 Td
(could)Tj
2.4491 0 Td
(be)Tj
1.1509 0 Td
(applied)Tj
3.1521 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4683 0 Td
(diagnosis)Tj
3.9572 0 Td
(of)Tj
1.0148 0 Td
(MS.)Tj
1.8141 0 Td
(The)Tj
1.7858 0 Td
(difficulty)Tj
-34.0041 -1.304 Td
(of)Tj
1.0147 0 Td
(predicting)Tj
4.3314 0 Td
(which)Tj
2.6475 0 Td
(patients)Tj
3.3675 0 Td
(will)Tj
1.6668 0 Td
(develop)Tj
3.3165 0 Td
(clinically)Tj
3.7757 0 Td
(definite)Tj
3.2655 0 Td
(MS)Tj
1.5874 0 Td
(currently)Tj
3.8891 0 Td
(presents)Tj
3.5206 0 Td
(a)Tj
0.6577 0 Td
(diagnostic)Tj
-33.0404 -1.2982 Td
(and)Tj
1.7291 0 Td
(therapeutic)Tj
4.7338 0 Td
(dilemma)Tj
3.7587 0 Td
([)Tj
0.83 0.64 0.02 0 k
(32)Tj
0 g
(].)Tj
2.075 0 Td
(This)Tj
1.9842 0 Td
(relationship)Tj
4.9889 0 Td
(was)Tj
1.7008 0 Td
(studied)Tj
3.1521 0 Td
(in)Tj
1.0375 0 Td
(a)Tj
0.652 0 Td
(cohort)Tj
2.8573 0 Td
(of)Tj
1.0148 0 Td
(patients)Tj
3.3675 0 Td
(with)Tj
1.9956 0 Td
(radio-)Tj
-35.0473 -1.2983 Td
(logically)Tj
3.5092 0 Td
(isolated)Tj
3.2825 0 Td
(syndrome)Tj
4.235 0 Td
(\(RIS\),)Tj
2.5625 0 Td
(clinically)Tj
3.7757 0 Td
(isolated)Tj
3.2881 0 Td
(syndrome)Tj
4.2293 0 Td
(\(CIS\))Tj
2.3811 0 Td
(and)Tj
1.7291 0 Td
(clinically)Tj
3.7814 0 Td
(definite)Tj
-32.7739 -1.2983 Td
(MS.)Tj
1.1962 -1.3039 Td
(In)Tj
1.1111 0 Td
(this)Tj
1.6725 0 Td
(field,)Tj
2.1996 0 Td
([)Tj
0.83 0.64 0.02 0 k
(33)Tj
0 g
(])Tj
1.8539 0 Td
(has)Tj
1.542 0 Td
(shown)Tj
2.846 0 Td
(that)Tj
1.7801 0 Td
(the)Tj
1.4684 0 Td
(mfVEP)Tj
3.1521 0 Td
(amplitude,)Tj
4.507 0 Td
(quantified)Tj
4.3087 0 Td
(as)Tj
1.0148 0 Td
(SNR,)Tj
2.279 0 Td
(performs)Tj
3.8778 0 Td
(best)Tj
1.8085 0 Td
(at)Tj
-36.6177 -1.2982 Td
(discriminating)Tj
6.0831 0 Td
(MS-risk)Tj
3.4355 0 Td
(subjects)Tj
3.3789 0 Td
(when)Tj
2.4038 0 Td
(applied)Tj
3.1521 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4683 0 Td
(visual)Tj
2.5115 0 Td
(field)Tj
1.9729 0 Td
(\(9.815)Tj
3.6 0 Td
(eccentricity,)Tj
5.0683 0 Td
(ring)Tj
1.8709 0 Td
(5\).)Tj
-34.7752 -1.2983 Td
(In)Tj
1.1111 0 Td
(the)Tj
1.4684 0 Td
(second)Tj
3.0103 0 Td
(experiment,)Tj
5.006 0 Td
(a)Tj
0.652 0 Td
(comparison)Tj
4.9776 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(variability)Tj
4.2236 0 Td
(of)Tj
1.0148 0 Td
(interocular)Tj
4.6374 0 Td
(latency)Tj
3.0501 0 Td
(values)Tj
2.6646 0 Td
(was)Tj
-35.4952 -1.3039 Td
(made)Tj
2.4207 0 Td
(between)Tj
3.532 0 Td
(the)Tj
1.4683 0 Td
(mfVEP)Tj
3.1521 0 Td
(signals)Tj
2.9027 0 Td
(filtered)Tj
3.067 0 Td
(using)Tj
2.3868 0 Td
(the)Tj
1.4683 0 Td
(standard)Tj
3.7247 0 Td
(method)Tj
3.3222 0 Td
(and)Tj
1.7348 0 Td
(the)Tj
1.4683 0 Td
(signals)Tj
2.9027 0 Td
(processed)Tj
-33.5506 -1.2983 Td
(using)Tj
2.3867 0 Td
(the)Tj
1.4683 0 Td
(EMD)Tj
2.4208 0 Td
(method.)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 385.285 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(EMD)Tj
2.4165 0 Td
(processing)Tj
4.9678 0 Td
(to)Tj
1.0417 0 Td
(improve)Tj
3.7134 0 Td
(mfVEP)Tj
3.3024 0 Td
(in)Tj
0.978 0 Td
(multiple)Tj
3.6 0 Td
(sclerosis)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.01949)Tj
4.089 0 Td
(64)Tj
0 g
2.0906 0 Td
(April)Tj
2.1827 0 Td
(20,)Tj
1.5874 0 Td
(2018)Tj
35.1357 0 Td
(3)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
82 0 obj
<>stream
endstream
endobj
83 0 obj
<>stream
endstream
endobj
84 0 obj
<>stream
endstream
endobj
85 0 obj
<>stream
endstream
endobj
86 0 obj
<>stream
endstream
endobj
87 0 obj
<>stream
endstream
endobj
88 0 obj
<>stream
endstream
endobj
89 0 obj
<>stream
endstream
endobj
90 0 obj
<>stream
endstream
endobj
91 0 obj
<>stream
endstream
endobj
92 0 obj
<>stream
endstream
endobj
93 0 obj
<>stream
endstream
endobj
94 0 obj
<>stream
endstream
endobj
95 0 obj
<>stream
endstream
endobj
96 0 obj
<>stream
endstream
endobj
97 0 obj
<>stream
endstream
endobj
98 0 obj
<>stream
BT
66.402 0 Td
(17)Tj
ET
Q
endstream
endobj
99 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 102 0 R/Contents 103 0 R/TrimBox[0 0 612 792]>>
endobj
101 0 obj
<>stream
x콋%u'f̎ww^l8bfw
C#0egBFZ-xM7
-o,hPylH%Pc9O#uU7C#++dRw @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ XL'bV)_9i m@ @ @}9C}tD BG MNO $A6(6"
l>|W
Uulg#"涪uvGA mD] 0gx9T>dVS1fUfNS%6Ň6%6եqA UCg0j2/@>'@scQ@47It$pS[90u2s c)J!JFBZbFLB -r